In this study, the machining characteristics of pulse short arc milling (SEAM) Ti6Al4V alloy were studied. regard, influence SEAM parameters on material removal rate (MRR), relative electrode wear ratio (REWR), and surface integrity is A wide variety processing parameters, including different voltages, frequencies, duty cycles, flushing pressures, rotation speeds, feed rates, are considered in ...

Using a high-throughput cell-based assay, we identified a nucleoside analogue 4-amino-6-hydrazino-7-beta-D-ribofuranosyl-7H-pyrrolo(2,3-d)-pyrimidine-5-carboxamide (ARC), which has the properties of a general transcriptional inhibitor. Specifically, ARC inhibits the phosphorylation of RNA polymerase II by positive transcription elongation factor-b, leading to a block in transcriptional elongati...

This paper presents a new algorithm that is capable of extracting circles from complicated and heavily corrupted images. The algorithm uses a least-squares fitting algorithm for arc segments. The arcs are segmented by using the short straight lines which are extracted by a fast line extraction algorithm. The arc segments are used to yield accurate circle parameters. Tests performed on synthetic...

Although APP mutations associated with inherited forms of Alzheimer's disease (AD) are relatively rare, detailed studies of these mutations may prove critical for gaining important insights into the mechanism(s) and etiology of AD. Here, we present a detailed biophysical characterization of the structural properties of protofibrils formed by the Arctic variant (E22G) of amyloid-beta protein (Ab...

Isochronal maps of ventricular activation were analyzed in dogs 3-5 days after ligation of the left anterior descending coronary artery utilizing a 64-channel multiplexer. Isochronal maps of the effective refractory period were determined from 62 epicardial sites and correlated with the activation maps. The ischemia occurring in the surviving epicardial layer prolonged refractoriness in a spati...

This special volume of Security Challenges contains contributions from leading experts and Pacific scholars that reflect on progress and prospects in the “Pacific arc”. This Introduction begins by identifying common themes that emerge from the contributions regarding the way in which Australia relates to the arc, and how the arc responds to Australia. It then summarises the contributors’ conclu...

The activity-regulated cytoskeletal-associated protein (Arc/Arg3.1) is an immediate-early gene that has been widely implicated in synaptic plasticity and in the consolidation of a variety of hippocampal- and amygdala-dependent memory tasks. The functional role of Arc/Arg3.1 in memory reconsolidation processes, however, has not been systematically studied. In the present study, we examined the r...

Situational awareness of Earth-orbiting particles is highly important for future human activities in space. For optical observations of debris, multiple observations must be combined in order to determine the orbit of the observed object. It is generally uncertain, however, whether two arbitrary tracks are of the same object, and solving this problem can be computationally intensive. In this pa...

To avoid breeding during unsuitable environmental or physiological circumstances, the reproductive axis adjusts its output in response to fluctuating internal and external conditions. The ability of the reproductive system to alter its activity appropriately in response to these cues has been well established. However, the means by which reproductively relevant cues are interpreted, integrated ...