Substrate utilization by heart muscle provides the fuel for both maintenance of structure and function of the myocardium and for ample reserve capacity to meet sudden surges in cardiac energy requirements. Many factors influence the balance of substrate uptake by the myocardium, but in general, utilization of lipids versus carbohydrates correlates to their concentration in the arterial blood. T...

An invitation from Eduardo Marbán, on the occasion of the 50th anniversary of Circulation Research, provides an opportunity to reflect on my understanding of the most important advance in regulation of cardiac metabolism. By the early 1950s, the major findings were the observation by Locke and Rosenheim in 1907 that glucose is used as a fuel by the isolated perfused heart and the observation by...

All tools in the DAVID Bioinformatics Resources aim to provide functional interpretation of large lists of genes derived from genomic studies. The newly updated DAVID Bioinformatics Resources consists of the DAVID Knowledgebase and five integrated, web-based functional annotation tool suites: the DAVID Gene Functional Classification Tool, the DAVID Functional Annotation Tool, the DAVID Gene ID ...

FcgammaR-mediated phagocytosis of IgG-coated particles is a complex process involving the activation of multiple signaling enzymes and is regulated by the inositol phosphatases PTEN (phosphatase and tensin homolog deleted on chromosome 10) and SHIP-1 (Src homology [SH2] domain-containing inositol phosphatase). In a recent study we have demonstrated that SHIP-2, an inositol phosphatase with high...

Plasma fueling with pellet injection, pacing of edge localized modes (ELMs) by small frequent pellets, and disruption mitigation with gas jets or injected pellets are some of the most important technological capabilities needed for successful operation of ITER. Tools are being developed at Oak Ridge National Laboratory that can be employed on ITER to provide the necessary core pellet fueling an...

Introduction On the morning of 15 March, 2000, phones began ringing in Washington, Virginia, and Massachusetts. Emails flew between the USA and the Bahamas. The event behind these communications was a mass stranding of beaked whales (Ziphiidae) in the northern Bahamas extending from Grand Bahama to the tip of Abaco (Evans and England, 2001). Over two days, 17 whales were reported on shore, of w...

This survey discusses recent developments in the context of spherical designs and minimal energy point configurations on spheres. The recent solution of the long standing problem of the existence of spherical t-designs on S with O(td) number of points by A. Bondarenko, D. Radchenko, and M. Viazovska attracted new interest to this subject. Secondly, D. P. Hardin and E. B. Saff proved that point ...

Pilot-fueling and nozzle-injection pressure are significant injection parameters, they have impacts on modern vehicles for enhancing the engine output, in addition to meeting rigorous tailpipe-exhaust emission standards. In this current work, influence of pilot-fueling nozzle-opening (NOP) performance tailpipe outcomes from a compression-ignition (CI) at higher varying load conditions was inves...

Recently Umemura, Fukue, & Mineshige (1997) proposed the radiative avalanche fueling to active galactic nuclei; gas accretion is driven by radiation drag exerted by stellar radiation from circumnuclear starburst regions. This mechanism is also interesting in terms of starburst-AGN connections. We therefore present observational tests for the radiative avalanche fueling. Our tests, however, show...

We present a conceptual design of a laser fusion experimental reactor (LIFT) and analyze the issues related to the fueling and chamber systems. The LIFT is designed on a scheme of three phases where each phase has specific goals and dedicated chambers driven by the same laser. Based on our understanding, the critical issues include the control of fuel loading in the fueling system and the stabi...