نتایج جستجو برای: shbg

تعداد نتایج: 1178  

2017
Adrian Heald Ian Laing David J. McLernon Rachelle Donn Andrew J. Hartland Anthony A. Fryer Mark Livingston

OBJECTIVE Sex hormone binding globulin (SHBG) is a marker of insulin resistance. Given established links between BMI and socioeconomic disadvantage, we investigated how SHBG varies by index of multiple deprivation (IMD). RESEARCH DESIGN AND METHODS Using laboratory data from a Midlands UK population of mixed ethnicity, we examined the relation between blood concentrations of SHBG and IMD in 1...

2010
Tomàs Pinós Anna Barbosa-Desongles Antoni Hurtado Albert Santamaria-Martínez Inés de Torres Jaume Reventós Francina Munell

BACKGROUND The human sex hormone-binding globulin (SHBG) gene comprises at least 6 different transcription units (TU-1, -1A, -1B, -1C, -1D and -1E), and is regulated by no less than 6 different promoters. The best characterized are TU-1 and TU-1A: TU-1 is responsible for producing plasma SHBG, while TU-1A is transcribed and translated in the testis. Transcription of the recently described TU-1B...

2018
Yael Sofer Nava Nevo Michal Vechoropoulos Gabi Shefer Etty Osher Nathan Landis Karen Tordjman Geoffrey L Hammond Naftali Stern

BACKGROUND Sex hormone-binding globulin (SHBG) is the main transporter of sex hormones in most vertebrates. Low SHBG levels have been linked to increased risk for diabetes and metabolic syndrome. Polymorphisms of the SHBG gene linked to low SHBG protein levels also strongly predicted increased risk of type 2 diabetes, thus raising the possibility that SHBG may play a role in the pathogenesis of...

Journal: :The Journal of clinical endocrinology and metabolism 2009
Erin S LeBlanc Carrie M Nielson Lynn M Marshall Jodi A Lapidus Elizabeth Barrett-Connor Kristine E Ensrud Andrew R Hoffman Gail Laughlin Claes Ohlsson Eric S Orwoll

CONTEXT The relationship between sex steroids and fracture is poorly understood. OBJECTIVE The objective of the study was to examine associations between nonvertebral fracture risk and bioavailable estradiol (bioE2), bioavailable testosterone (bioT), and SHBG. DESIGN This was a case-cohort study. SETTING The Osteoporotic Fractures in Men Study (MrOS) was conducted in a prospective U.S. co...

Journal: :The Journal of steroid biochemistry and molecular biology 2011
Mohammad Reza Safarinejad Nayyer Shafiei Shiva Safarinejad

Sex hormone binding globulin (SHBG) is involved in delivering sex hormones to target tissues. We investigated the association between the (TAAAA)n repeat polymorphism, and Asp327Asn polymorphism in the SHBG gene with semen quality and idiopathic male infertility. We studied 168 men with idiopathic infertility [oligoasthenoteratozoospermia (OAT)] and equal number of age-matched normal controls. ...

Journal: :Journal of andrology 1989
S R Plymate J S Tenover W J Bremner

The circadian pattern in levels of serum total testosterone (T) in men becomes blunted with normal aging. However, because T not bound to sex hormone-binding globulin (non-SHBG-T) is felt to be a better representative of biologically available T than is total T, the possibility of a 24-h variation in non-SHBG-T in young men and the possibility that aging is associated with a blunting of that rh...

Journal: :Collegium antropologicum 2016
Marina Šprem Goldštajn Karlo Toljan Franjo Grgić Ivana Jurković Dinka Pavičić Baldani

Sex hormone binding globulin (SHBG) is an important protein, not only for transporting sex steroids which is its primary role, but with the discovery of a specific receptor that binds SHBG, a novel approach regarding classic ‘free-hormone hypothesis’ should be implemented. Research in SHBG gene and it expression has been done, as well as cellular signaling that controls it. It provides signific...

Journal: :The Journal of clinical endocrinology and metabolism 2000
A W van den Beld F H de Jong D E Grobbee H A Pols S W Lamberts

In the present cross-sectional study of 403 independently living elderly men, we tested the hypothesis that the decreases in bone mass, body composition, and muscle strength with age are related to the fall in circulating endogenous testosterone (T) and estrogen concentrations. We compared various measures of the level of bioactive androgen and estrogen to which tissues are exposed. After exclu...

2016
Ningjian Wang Hualing Zhai Chaoxia Zhu Qin Li Bing Han Yi Chen Chunfang Zhu Yingchao Chen Fangzhen Xia Dongping Lin Yingli Lu

This study aimed to explore the combined associations of 25(OH)-vitamin D and sex hormone binding globulin (SHBG) with nonalcoholic fatty liver disease (NAFLD) in men and postmenopausal women. Our data, which were based on the population, were collected from 16 sites in East China in 2014. There were 2700 men with a mean age of 53 years and 1461 women over 55 who were considered postmenopausal ...

2017
A. J. da Silva E. S. Santos

Sex hormone-binding globulin (SHBG) is a binding protein that regulates availability of steroids hormones in the plasma. Although best known as steroid carrier, studies have associated SHBG in modulating behavioral aspects related to sexual receptivity. Among steroids, estradiol (17β-estradiol, oestradiol or E2) is well recognized as the most active endogenous female hormone, exerting important...

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