UNLABELLED The importance of the kidney in glucose homeostasis has been recognized for many years. Recent observations indicating a greater role of renal glucose metabolism in various physiologic and pathologic conditions have rekindled the interest in renal glucose handling as a potential target for the treatment of diabetes. The enormous capacity of the proximal tubular cells to reabsorb the ...

Plasma glucose is filtered freely through the glomerular barrier. In a 70-kg adult with a glomerular filtration rate of 120 mL $ min per 1.73 m and an average, around-the-clock plasma glucose concentration of 120 mg/dL (6.7 mmol/L), ;200 g of glucose are transferred daily from the bloodstream into the preurine. If nothing else happened, the whole-body mass of free glucose (some 20 g in a distri...

A majorization relating the singular values of an oo-diagonal block of a Hermitian matrix and its eigenvalues is obtained. This basic majorization inequality implies various new and existing results.

This paper presents majorization results for PH-generators. Based on the majorization results, bounds on the moments and Laplace-Stieltjes transforms of phase-type distributions are found. Exponential distributions and Coxian distributions are identified to be extremal PH-distributions with respect to all the moments and Laplace-Stieltjes transforms for certain subsets of PH-distributions. UN C...

We study the conceptmatrix majorization: for two real matrices A and B having m rows we say that A majorizes B if there is a row-stochastic matrix X with AX = B. A special case is classical notion of vector majorization. Several properties and characterizations of matrix majorization are given. Moreover, interpretations of the concept in mathematical statistics are discussed and some combinator...

Transport in the colon of the domestic fowl switches from sodium-linked hexose and amino acid cotransport on high-salt intake to amiloride-sensitive sodium channel expression on low-salt (LS) diets. The present experiments were designed to investigate the role of aldosterone in suppression of the colonic sodium-glucose luminal cotransporter (SGLT). LS-adapted hens were resalinated with or witho...

In this paper we study the concept of Latin-majorizati-\on. Geometrically this concept is different from other kinds of majorization in some aspects. Since the set of all $x$s Latin-majorized by a fixed $y$ is not convex, but, consists of union of finitely many convex sets. Next, we hint to linear preservers of Latin-majorization on $ mathbb{R}^{n}$ and ${M_{n,m}}$.

in this paper we study the concept of latin-majorizati-on. geometrically this concept is different from other kinds of majorization in some aspects. since the set of all $x$s latin-majorized by a fixed $y$ is not convex, but, consists of :union: of finitely many convex sets. next, we hint to linear preservers of latin-majorization on $ mathbb{r}^{n}$ and ${m_{n,m}}$.

OBJECTIVE Sodium-glucose cotransporter 2 (SGLT-2) inhibitors are the most recently approved antihyperglycemic medications. We sought to describe their association with euglycemic diabetic ketoacidosis (euDKA) in hopes that it will enhance recognition of this potentially life-threatening complication. RESEARCH DESIGN AND METHODS Cases identified incidentally are described. RESULTS We identif...

Inhibitors of sodium-glucose cotransporter (SGLT)2 are a new class of oral drugs for type 2 diabetic patients that reduce plasma glucose levels by inhibiting renal glucose reabsorption. There is increasing evidence showing the beneficial effect of SGLT2 inhibitors on glucose control; however, less information is available regarding the impact of SGLT2 inhibitors on cardiovascular outcomes. The ...