نتایج جستجو برای: sfn

تعداد نتایج: 599  

2007
Guoxiang Shen Tin Oo Khor Rong Hu Siwang Yu Sujit Nair Chi-Tang Ho Bandaru S. Reddy Harold L. Newmark

Cancer chemopreventive agent sulforaphane (SFN) and dibenzoylmethane (DBM) showed antitumorigenesis effects in several rodent carcinogenesis models. In this study, we investigated the cancer chemopreventive effects and the underlying molecular mechanisms of dietary administration of SFN and DBM alone or in combination in the Apc mice model. Male Apc mice (12 per group) at age of 5 weeks were gi...

Journal: :Journal of immunology 2010
Hyung Sun Youn Yoon Sun Kim Zee Yong Park So Young Kim Na Young Choi Sun Myung Joung Jung A Seo Kyung-Min Lim Mi-Kyoung Kwak Daniel H Hwang Joo Young Lee

TLRs are pattern recognition receptors that detect invading microorganisms and nonmicrobial endogenous molecules to trigger immune and inflammatory responses during host defense and tissue repair. TLR activity is closely linked to the risk of many inflammatory diseases and immune disorders. Therefore, TLR signaling pathways can provide efficient therapeutic targets for chronic diseases. Sulfora...

2012
Carmela Fimognari Monia Lenzi Piero Sestili Eleonora Turrini Lorenzo Ferruzzi Patrizia Hrelia Giorgio Cantelli-Forti

BACKGROUND The isothiocyanate sulforaphane (SFN) possesses interesting anticancer activities. However, recent studies reported that SFN promotes the formation of reactive oxygen species (ROS) as well as DNA breakage. METHODOLOGY/PRINCIPAL FINDINGS We investigated whether SFN is able to damage RNA, whose loss of integrity was demonstrated in different chronic diseases. Considering the ability ...

2014
José Miguel P. Ferreira de Oliveira Maria Costa Tiago Pedrosa Pedro Pinto Catarina Remédios Helena Oliveira Francisco Pimentel Luís Almeida Conceição Santos

Sulforaphane (SFN) is a naturally-occurring isothiocyanate best known for its role as an indirect antioxidant. Notwithstanding, in different cancer cell lines, SFN may promote the accumulation of reactive oxygen species (ROS) and cause cell death e.g. by apoptosis. Osteosarcoma often becomes chemoresistant, and new molecular targets to prevent drug resistance are needed. Here, we aimed to deter...

2017
Anna Lewinska Jagoda Adamczyk-Grochala Anna Deregowska Maciej Wnuk

Cancer cells are characterized by genetic and epigenetic alterations and phytochemicals, epigenetic modulators, are considered as promising candidates for epigenetic therapy of cancer. In the present study, we have investigated cancer cell fates upon stimulation of breast cancer cells (MCF-7, MDA-MB-231, SK-BR-3) with low doses of sulforaphane (SFN), an isothiocyanate. SFN (5-10 µM) promoted ce...

2017
Zongxian Jiao Jiachen Chang Jing Li Dengmei Nie Huijuan Cui Dongfang Guo

Cigarette smoking is a primary risk factor for chronic obstructive pulmonary disease (COPD), as it damages epithelial cells through a variety of mechanisms. Sulforaphane (SFN) is an antioxidant agent, which exerts protective effects against cell damage by activating the nuclear factor erythroid 2 like 2 (NFE2L2; Nrf2). The present study was undertaken to investigate the effects and underlying m...

2014
Kristin Samuelsson Konstantinos Kostulas Magnus Vrethem Arndt Rolfs Rayomand Press

BACKGROUND AND PURPOSE The etiology of small fiber neuropathy (SFN) often remains unclear. Since SFN may be the only symptom of late-onset Fabry disease, it may be underdiagnosed in patients with idiopathic polyneuropathy. We aimed to uncover the etiological causes of seemingly idiopathic SFN by applying a focused investigatory procedure, to describe the clinical phenotype of true idiopathic SF...

2015
Liping Wang Zhufang Tian Qi Yang Heng Li Haixia Guan Bingyin Shi Peng Hou Meiju Ji

Sulforaphane (SFN), a natural compound derived from broccoli/broccoli sprouts, has been demonstrated to be used as an antitumor agent in different types of cancers. However, its antitumor effect in thyroid cancer remains largely unknown. The aim of the study was to investigate the therapeutic potential of SFN for thyroid cancer and explore the mechanisms underlying antitumor effects of SFN by i...

2017
Bo Zhao Wenwei Gao Xiang Gao Yan Leng Min Liu Jiabao Hou Yang Wu

Sulforaphane (SFN), an antioxidant derived from cruciferous vegetables, exerts antioxidant capacity and protects organ against oxidative damage. However, the effects of SFN on sepsis-induced acute lung injury (ALI) have not been determined. The aim of this study was to investigate the effect of SFN in sepsis-induced ALI and the role of Nrf2/HO-1 in this process. Rats were subjected to either sh...

2015
Xueqi Qu Maren Pröll Christiane Neuhoff Rui Zhang Mehmet Ulas Cinar Md. Munir Hossain Dawit Tesfaye Christine Große-Brinkhaus Dessie Salilew-Wondim Ernst Tholen Christian Looft Michael Hölker Karl Schellander Muhammad Jasim Uddin

Histone acetylation, regulated by histone deacetylases (HDACs) is a key epigenetic mechanism controlling gene expressions. Although dendritic cells (DCs) are playing pivotal roles in host immune responses, the effect of epigenetic modulation of DCs immune responses remains unknown. Sulforaphane (SFN) as a HDAC inhibitor has anti-inflammatory properties, which is used to investigate the epigenet...

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