OBJECTIVE To estimate the relationship between the risk of preeclampsia and two thrombophilia gene single-nucleotide polymorphisms (SNPs), the factor V G1691A SNP and the prothrombin G20210A SNP. DATE SOURCES A systematic search of the English-language literature up to November 2012 was performed using Medline and EMBASE. Search terms included "preeclampsia," "thrombophilia," "factor V Leiden...

Serial measurements of the plasma concentration of fibrinopeptide A, thrombin-increasable fibrinopeptide B (reflecting B beta 1-42), desarginyl fibrinopeptide B, beta thromboglobulin, and platelet factor 4 were made before, during, and after delivery in patients with preeclampsia/eclampsia. The data were correlated with routine coagulation studies, hematologic and renal status, as well as with ...

Elevated blood pressure in pregnancy may represent chronic hypertension (occurring before 20 weeks' gestation or persisting longer than 12 weeks after delivery), gestational hypertension (occurring after 20 weeks' gestation), preeclampsia, or preeclampsia superimposed on chronic hypertension. Preeclampsia is defined as hypertension and either proteinuria or thrombocytopenia, renal insufficiency...

The complement cascade is activated in normal pregnancy, and excessive complement activation propagates the systemic inflammatory response in severe preeclampsia. Consequently, biomarkers of complement dysregulation may be useful for prediction or treatment of disease. Because renal damage with proteinuria is a characteristic pathological feature of preeclampsia, we hypothesized that complement...

Objective: To evaluate if computerized cardiotocography (cCTG) twice a day improved maternal or perinatal outcome compared to daily cCTG in women with severe preeclampsia remote from term. Study design: This is a 5 year population-based observational study. Women with severe preeclampsia remote from term (<34 weeks) monitored with cCTG twice a day were compared to women with severe preeclampsia...

background: severe preeclampsia is a quite well-known entity with high incidence of both maternal and fetal morbidity and mortality. although little is known about its etiology, inherited disorders of hemostasis and antiphospholipid syndrome have been postulated as common causes. the present study was conducted to evaluate the association of these two entities with preeclampsia in a group of ir...

Objectives: Preeclampsia is best described as a pregnancy-specific syndrome of reduced organ perfusion secondary to vasospasm and endothelial activation. It is severe and clinically important manifestations of placental insufficiency. Our purpose was to study DUSP1 expression in normal human pregnancy and preeclampsia. Study design: We used ELISA, RT-PCR and Immuno-histochemistry to characteriz...

OBJECTIVES Preeclampsia is divided into early-onset (delivery before 34 weeks of gestation) and late-onset (delivery at or after 34 weeks) subtypes, which may rise from different etiopathogenic backgrounds. Early-onset disease is associated with placental dysfunction. Late-onset disease develops predominantly due to metabolic disturbances, obesity, diabetes, lipid dysfunction, and inflammation,...

Preeclampsia is the most common hypertensive disease of pregnancy, affecting 5-8% of pregnancies (Saftlas et al., 1990) and accounting for nearly 18% of maternal deaths (ACOG, 2002) in the United States. Little change has been noted in the incidence of this disease in the United States during the national data-collection periods of 19931997 and 2001-2005 (Berg et al., 2009). Preeclampsia is als...

Although smoking during pregnancy may lead to many adverse effects, such as fetal growth restriction, placental abruption, stillbirth, and preterm labor, smoking is the only environmental exposure known to consistently reduce the risk of preeclampsia and gestational hypertension.1 The article by Wikström et al2 is a major step forward in understanding this protective effect. Using data from the...