AROMATICINE (SYSTEMATIC NAME: 4a,8-dimethyl-3-methyl-ene-3,3a,4,4a,7a,8,9,9a-octa-hydro-azuleno[6,5-b]furan-2,5-dione), C(15)H(18)O(3), is a natural lactone isolated from Amblyopappus pusillus. The mol-ecular structure and conformation agree with the results of Romo, Joseph-Nathan & Díaz [(1964 ▶). Tetra-hedron, 20, 79-85]. The fused-ring system contains a seven-membered ring in a twist-boat co...

THE TITLE COMPOUND [SYSTEMATIC NAME: 3,8-dihydr-oxy-3-(hydroxy-meth-yl)-9-methyl-6-methyl-enedeca-hydro-azuleno[4,5-b]furan-2(3H)-one], C(15)H(22)O(5), is a sesquiterpene lactone showing the typical tricyclic guaianolide skeleton which has been isolated, together with other related metabolites, from the plant Centaurea musimomum. The present study confirms the mol-ecular structure, assigned by ...

Parthenin (a sesquiterpene lactone) is a major constituent of parthenium hysterophorus –a noxious weed known for its environmental and health hazardous properties. . It is responsible for imparting the several properties to this weed such as allelpathy, autotoxicity and allergencity. Further, anticancerous, antiameobic and antimalarial properties of the weed are also credited to parthenin. The ...

A population of Parthenium hysterophorus collected in Salta Argentina afforded two ambrosanolides, 2beta-hydroxycoronopilin and 1alpha,2beta,4beta-trihydroxypseudoguaian-6beta,12-olide, as well as five known others. Plants of the fructification from those transplanted from the Puna Argentina at 1200 m over the sea level produced hymenin.

The three-ring eudesmanolide, C(15)H(16)O(3), is a natural product isolated from Dicoma anomala Sond. (Asteraceae). The compound contains an endo-exo cross conjugated methyl-enecyclo-hexenone ring with an envelope conformation trans-fused with cyclo-hexane and trans-annelated with an α-methyl-ene γ-lactone. The absolute structure was assigned by optical rotation measurements compared to those f...

Dehydro-leucodin [systematic name: (1S,6S,2R)-9,13-dimeth-yl-5-methyl-ene-3-oxatricyclo-[8.3.0.0(2,6)]trideca-9,12-diene-4,11-dione], C(15)H(16)O(3), is a guanolide isolated from Artemisia douglasiana. The fused-ring system contains a seven-membered ring that adopts a chair conformation, a fused planar cyclo-pentenone ring and a five-membered lactone ring fused in envelope conformation. The abs...

Herbal extracts containing sesquiterpene lactones have been extensively used in traditional medicine and are known to be rich in α,β-unsaturated functionalities that can covalently engage target proteins. Here we report synthetic methodologies to access analogues of deoxyelephantopin, a sesquiterpene lactone with anticancer properties. Using alkyne-tagged cellular probes and quantitative proteo...