The biotransformation of dihydro-epi-deoxyarteannuin B (compound 1) was investigated by using suspension-cultured cells of Averrhoa carambola. One novel sesquiterpene, 7α-hydroxy-dihydro-epideoxyarteannuin B (compound 2, 29.02%), and one known sesquiterpene, 3-α-hydroxy-dihydro-epideoxyarteannuin B (compound 3, 23.26%), were obtained upon the addition of the substrate (compound 1). All the biot...

Trypanocidal constituents of Pogostemon cablin were investigated. Activity guided isolation of the acetone extract resulted in isolation of three new sesquiterpene hydroperoxides 1-3, together with a known sesquiterpene, patchouli alcohol (4). In vitro minimum lethal concentrations of the hydroperoxides 1-3 against epimastigotes of Trypanosoma cruzi were 0.84 microM (1), 1.7 microM (2) and 1.7 ...

Anna Aiello, Ernesto Fattorusso*, and Marialuisa Menna Dipartimento di Chimica delle Sostanze Naturali, Via D. Montesano 49, 1-80131 Napoli, Italy Z. Naturforsch. 48b, 209-212(1993); received September 18. 1992 Spongidae, Smenospongia aurea, Sesquiterpene, Antibiotic, NM R Spectra A new sesquiterpene phenol, containing the rather uncommon chlorine atom, was isolated from a sample of Smenospongi...

Chemical investigation of the Bulgarian species Tanacetum. parthenium, T. millefolium, T. achilleifolium, T. corymbosum and T. macrophyllum afforded in addition to 24 known sesquiterpene lactones a new 12, 8-eudesmanolide 22. Besides, four known highly oxigenated terpenoids and a new keto-diol 30 of the rare iphionane skeleton were also isolated. The structures were elucidated on the basis of t...

Objective During the last three decades sesquiterpenoid lactones have emerged as one of the largest groups of plant products with over 3000 naturally occurring substances known. The genus Artemisia characteristically contains this biologically active type of secondary metabolites. With respect to increasing interest in the cytotoxic, antibiotic, phototoxic and antineoplastic activities of sesq...

Sesquiterpene lactones display a wide variety of biological effects such as antiviral, anti-inflammatory and cytotoxic activity. In previous studies some derivatives of sesquiterpene lactones were prepared to be tested as antiviral and/or cytoxic agents. In the present report we describe the effects of seven modified sesquiterpene lactones on the proliferation of several cancer cell lines. We d...

Polygodial, a valuable sesquiterpene dialdehyde featuring an epimerizable stereocenter was efficiently extracted and isolated in gram-scale quantities (3.3% w/w) from Tasmannia lanceolata (Tasmanian native pepper) via a recently developed rapid pressurised hot water extraction (PHWE) technique that utilises an unmodified household espresso machine. This method was compared to the maceration of ...

Sesquiterpene composition at two sites representative of the southeastern U.S. is similar with β-caryophyllene and humulene dominating ozone reactivity.

Artemisinin from the plant Artemisia annua is the most potent pharmaceutical for the treatment of malaria. In the plant, the sesquiterpene cyclase amorphadiene synthase, a cytochrome-dependent CYP450, and an aldehyde reductase convert farnesyl diphosphate (FDP) into dihydroartemisinic aldehyde (DHAAl), which is a key intermediate in the biosynthesis of artemisinin and a semisynthetic precursor ...