Established methods for determining the serum uric acid concentration are colorimetric, enzymatic, or combination of the two. An alternative method, based on the affinity of purines for polyacrylamide resin, has been developed. Uric acid, more strongly adsorbed than other major serum constituents, elutes later (with phosphate buffer, pH 7) from a poly. acrylamide column. The separated serum uri...

Background We aimed to estimate the glomerular filtration rate (GFR) in women with polycystic ovary syndrome (PCOS) and to determine the relationship between GFR with C-reactive protein (CRP) and uric acid. MaterialsAndMethods In this cross-sectional study, one-hundred and forty PCOS women and 60 healthy subjects were evaluated. The study was carried out at Endocrinology Outpatient Clinic, Erzu...

INTRODUCTION Toxicity by oxygen radicals has been considered as an important cause of cancer. It is proposed that the antioxidant properties of uric acid may act to prevent formation of oxygen radicals and thereby protect against carcinogenesis. This study aims to assess the role of uric acid in the aetiology of oral cancer. MATERIALS AND METHODS Thirty one oral cancer patients and thirty nor...

BACKGROUND In some western populations, increased serum uric acid has been positively associated with cardiovascular disease, possibly because hyperuricaemia could be an untoward part of the insulin-resistant metabolic syndrome. However, there is evidence that uric acid is a free radical scavenger capable of inhibiting LDL oxidation. Amongst the traditional horticulturalists of Kitava, Trobrian...

An automated procedure is presented for the enzymatic determination of serum uric acid on both the AutoAnalyzer and the Robot Chemist. The procedure measures as the neocuproine complex, the difference in the amount of Cu+ formed by reaction of a Cu++ aIkanoIamine buffered solution with serum uric acid under precisely controlled conditions before and after uricase treatment of the serum. The dif...

BACKGROUND Some experimental evidence suggests that uric acid impairs endothelial function. It is controversial if high uric acid levels and impaired endothelial function are related in healthy adults. In addition, the effect of uric acid on endothelial cells (ECs) of humans is unexplored. METHODS Data of 107 healthy adult volunteers were analyzed. The association between serum uric acid and ...

Elevated serum uric acid level is associated with obesity, insulin resistance, diabetes, nephropathy, and hypertension. Epidemiologic studies suggest that serum uric acid levels are heritable. We sought to identify chromosomal regions harboring quantitative trait loci that influence serum uric acid in Mexican Americans using data from 644 participants in the San Antonio Family Heart Study. Seru...

The rapid infusion of fructose, but not of diffusely inhibit renal proximal tubular glucose or galactose, to normal male function. Data are presented that suggest volunteers produced a 30% rise in serum that fructose infusions may concomitantly uric acid. All three hexoses increased the stimulate the conversion of preformed renal excretion of uric acid, phosphate, adenine nucleotides to uric ac...

Background: Previous studies show that serum level of uric acid is significantly correlated with mortality and functional outcome in patients with ischemic stroke and according to some other studies, ischemic stroke is associated with stenosis of some stenoisis of somespecific brain vessels. The aim of this study was to investigate the frequency of hyperuricemia and its associa...