BACKGROUND Lyme disease is diagnosed by 2-tiered serologic testing in patients with a compatible clinical illness, but the significance of positive test results in low-prevalence regions has not been investigated. METHODS We reviewed the medical records of patients who tested positive for Lyme disease with standardized 2-tiered serologic testing between 2005 and 2010 at a single hospital syst...

OBJECTIVE To address the questions and challenges commonly faced by primary care physicians when ordering serologic tests for celiac disease (CD) and provide practical clinical tips to help in the interpretation of test results. SOURCES OF INFORMATION MEDLINE was searched from 2000 to 2015 for English-language guidelines on the diagnosis and management of CD published by professional gastroen...

BACKGROUND Serologic surveillance of Avian Influenza (AI) viruses is carried out by the hemagglutination inhibition (HI) test using reference reagents. This method is recommended by animal health organizations as a standard test to detect antigenic differences (subtypes) between circulating influenza virus, vaccine- and/or reference- strains. However, significant discrepancies between reference...

We report here the serologic detection of a cell surface antigen common to cells transformed by the Abelson murine leukemia virus (A-MuLV) and to normal hematopoietic cells from certain strains of mice. Serum from C57BL/6 mice hyperimmunized with syngeneic A-MuLV lymphoma cells was cytotoxic for the immunizing cells; this reaction was used as the serologic test system for recognition of A-MuLV ...

BACKGROUND Serologic methods have been used widely to test for celiac disease and have gained importance in diagnostic definition and in new epidemiologic findings. However, there is no standardization, and there are no reference protocols and materials. METHODS The European working group on Serological Screening for Celiac Disease has defined robust noncommercial test protocols for immunoglo...

while an important infectious disease in the united states and eurasia, lyme disease is rare in iran. we present a 9-year old boy admitted in children’s medical center in december 2001 with final diagnosis of lyme disease. on admission he showed arthritis and a history of previous skin lesions. serologic examination including enzyme–linked immunosorbent assay and western blot was positive for l...

Hepaxpert-I is an expert system that interprets the results of routine serologic tests for infection with hepatitis A or B virus. The tests measure antibody to the hepatitis A virus (anti-HAV), IgM antibody to the hepatitis A virus (IgM anti-HAV), hepatitis A virus (HAV) in the stool, hepatitis B surface antigen (HBsAg) and antibody (anti-HBs), antibody to hepatitis B core antigen (anti-HBc and...

Herpes simplex virus type 2 infection is one of the most common sexually transmitted diseases. Because presentation is often atypical or subclinical, serologic testing is necessary for diagnosis, treatment, and counseling. In an urban clinic that specializes in the treatment of sexually transmitted disease, a new point-of-care rapid serologic test was compared with enzyme-linked immunosorbent a...

background: human pathogens that can cause infertility may also affect sperm count and quality. viral infections can be considered as direct and/or indirect cause of male factor infertility. objective: our goal was to investigate the prevalence of herpes simplex virus in the semen of infertile men attending the avicenna infertility clinic, and to compare it with the herpes virus serology result...