Background Trauma patients are characterised by alterations in the immune system, increased exposure to infectious complications, sepsis and potentially organ failure and death. Glutamine supplementation to parenteral nutrition has been proven to be associated with improved clinical outcomes. However, glutamine supplementation in patients receiving enteral nutrition and its best route are still...

Methods This is a prospective cohort study involving severe sepsis patients admitted to ICU Hasan Sadikin General Hospital Bandung Indonesia between period of August 2013 January 2014. Data of type of admission, initial Sequential Organ Failure Assessment (SOFA) score, mortality and length of stay (LOS) in ICU were collected. Severity of illness was measured using Acute Physiology and Chronic H...

The Third International Consensus Definitions for Sepsis and Septic Shock has recently defined sepsis as a life-threatening organ dysfunction caused by a dysregulated host response to infection. Organ dysfunctions in this consensus definition were identified as an organ-specific Sequential [Sepsis-related] Organ Failure Assessment (SOFA) score ≥ 2 points. The quick SOFA (qSOFA) considers altere...

Multiple organ failure (MOF) is a common cause of death in intensive care unit (ICU) patients [1]. But what are the mechanisms underlying the development of MOF? Why, when we can support many of the individual organs, e.g., the kidneys with extracorporeal renal support, the lungs with mechanical ventilation, etc., do we all too often end up withholding/withdrawing these life-supporting therapie...

OBJECTIVE To evaluate the performance of Sequential Organ Failure Assessment (SOFA) score in cases of severe maternal morbidity (SMM). DESIGN Retrospective study of diagnostic validation. Setting. An obstetric intensive care unit (ICU) in Brazil. Population. 673 women with SMM. MAIN OUTCOME MEASURES mortality and SOFA score. Methods. Organ failure was evaluated according to maximum score fo...