Sepsis is a serious disease with high mortality and has been hot research topic in medical recent years. With the continuous reporting of in-depth on pathological mechanisms sepsis, various compounds have developed to prevent treat sepsis. Natural small-molecule play vital roles prevention treatment sepsis; for example, such as resveratrol, emodin, salidroside, ginsenoside, others can modulate ...

Sepsis is a systemic inflammatory response syndrome that caused by infection. It one of the most common critical diseases clinically. Although more anti-inflammatory drugs are available, treatment options for sepsis remain limited. The nucleotide-binding domain-like receptor protein 3 (NLRP3) inflammasome multiprotein complex has been implicated in development and evolution other autoimmune dis...

Sepsis accounts for a major cause of morbidity and mortality in surgical and medical ICU. The current pharmacological management still hovers around early management of patients with antibiotics yet fails to adequately personalise the treatment on patient characteristics. Even today the severity of sepsis is assessed by a variety of biochemical and clinical markers that further helps to take a ...

The early events of severe sepsis set in motion a cascade of events that significantly contributes to the morbidity and mortality observed during the first few days of this syndrome. Although sepsis is a deadly, acute disease, survivors also suffer long-term consequences. Clinical data underscore subsequent high mortality rates associated with patients who are long-term survivors of the acute s...

The novel type coronoviruses spreaded all around the world, and caused a global health problem world since 2019. number of pregnant women infected by new have been on rise. COVID-19 infection in pregnancy can be experienced with different symptoms as like asymptomatic infection, mild disease (no evidence pneumonia or hypoxia), moderate (viral pneumonia), severe (severe pneumonia) critical illne...

background: neonatal sepsis is a life-threatening disease with an incidence of 1 to 10 per 1000 live births and a mortality rate of 15% to 50%. the clinical signs are non-specific and indistinguishable from those caused by a variety of neonatal noninfectious disorders. objective: the aim of this study was to determine the importance of cd64 expression (fcgri), a neutrophil surface marker, in ea...

Abstract Patients infected with SARS-CoV-2 can experience variable susceptibility and sepsis-like immune dysfunction. Also, patients comorbidities such as previous septic events are more likely to be hospitalized succumb COVID19 complications. However, the extent which respiratory beta-coronavirus pathology is dose dependent produces dysregulation in an experimental murine model not completely ...

Background and Objective: Due to the importance of acute kidney injury associated in patients with sepsis and the impact of various factors on mortality and hospital stay of these patients, this study was conducted to investigate the clinical features and risk factors for acute kidney injury in patients with sepsis. In addition, we examined whether the severity of acute kidney injury affected c...

Sepsis caused by Gram-positive bacterial pathogens is a major fatal disease but its molecular basis remains elusive. Toll-like receptor 2 (TLR2) has been implicated in the orchestration of inflammation and sepsis but its role appears to vary for different pathogen species and clones. Accordingly, Staphylococcus aureus clinical isolates differ substantially in their capacity to activate TLR2. He...