OBJECTIVES to explore the associations between spatiotemporal gait parameters and falls in cognitively impaired older people and to investigate whether sensorimotor and neuropsychological factors mediate the association between gait performance and falls. DESIGN prospective cohort study with a 1 year follow-up. SETTING community-dwelling sample. PARTICIPANTS sixty-four participants (62-96...

The human spinal cord contains segregated sensory and motor pathways that have been difficult to quantify using conventional magnetic resonance imaging (MRI) techniques. Multiple sclerosis is characterized by both focal and spatially diffuse spinal cord lesions with heterogeneous pathologies that have limited attempts at linking MRI and behaviour. We used a novel magnetization-transfer-weighted...

BACKGROUND Although the consequences of spinal cord injury (SCI) within the spinal cord and peripheral nervous system have been studied extensively, the influence of SCI on supraspinal structures during recovery remains largely unexplored. OBJECTIVE To assess temporal changes in cortical sensorimotor representations beginning in the subacute phase following SCI and determine if an association...

previous studies had reported that extracellular levels of ascorbic acid have modulatory effects on dopamine receptors. both ascorbic acid and dopamine receptor have an important role in learning and memory processes. however, the central interaction between ascorbic acid and dopamine d2 receptor on spatial learning and memory has not yet been elucidated. all experiments were carried out on mal...

Stroke is one of the leading causes mortality and morbidity in adult population, resulting significant cognitive sensorimotor impairments affecting one-half body most patients. The limitations that are attributed to trunk impairment affect postural respiratory functions due either spasticity or weakness muscles, including diaphragm. Physiotherapy effective interdisciplinary stroke management, w...

This study provides a comprehensive behavioral characterization during aging of transgenic mice bearing both presenilin-1 (PS1) and amyloid precursor protein (APP(670,671)) mutations. Doubly transgenic mice and non-transgenic controls were evaluated at ages wherein beta-amyloid (Abeta) neuropathology in APP+PS1 mice is low (5-7 months) or very extensive (15-17 months). Progressive cognitive imp...

Given mounting evidence that auditory, visual and/or motor dysfunction may not cause developmental dyslexia, but are often associated with it, the present paper proposes a new neurological model of dyslexia which explains how a specific phonological deficit might arise, and sometimes occur together with a more general sensorimotor syndrome. Based on a review of the neurology of dyslexia, the mo...

Objective: This study was conducted to investigate the relationship between trunk control and lower extremity sense, balance gait in stroke individuals.
 Methods: Thirty subacute chronic patients were included (mean age 52. 2 14.4 years). Trunk Impairment Scale (TIS) Turkish version of Postural Assessment for Stroke Patients (PASS-T) used evaluating body control, Tinetti Balance Test (TBT...

Cortical control of the sensory output of muscle spindles was studied in thirteen anesthetized cats in the present experiment. Gamma motoneuron activity was monitored during electrical stimulation of the sensorimotor cortex while recording from single primary afferents from the tenuissimus muscle. Findings are as follows: 1. The state of anesthesia is crucial in obtaining reproducible resu...

Sleep is a key process in neurodevelopment and essential for the maturation of fundamental brain functions. Premature birth can disturb initial steps sleep maturation, which may contribute to impairment neurodevelopment. It thus understand various states quality cerebral function each vigilance state, as well development cyclicity, at-risk neonatal infants, particularly those born premature. Th...