Cross-inhibition by quorum-sensing pheromones between Staphylococcus aureus and Staphylococcus epidermidis was investigated using all known S. aureus agr pheromone subgroups. All S. aureus subgroups were sensitive towards the S. epidermidis pheromone, with the exception of the recently identified subgroup 4. The subgroup 4 pheromone was also the only S. aureus pheromone able to inhibit the S. e...

background: macrolides, lincosamides and type b streptogramins (mlsb) are commonly used for the treatment of staphylococcal infections. inducible mlsb resistance (imlsb) cannot be identified by standard methods of antibiotic susceptibility testing. d-test appears to be a reliable indicator of imlsb strains. the aim of this study was to determine the prevalence of clindamycin resistance phenotyp...

Clindamycin has been used successfully to treat pneumonia and soft-tissue infections caused by methicillin-resistant Staphylococcus aureus. However, inducible clindamycin resistance has been described as a cause of treatment failure of such infections. A total of 159 staphylococcal isolates from different clinical specimens from burn patients in Tripoli Burn Center were tested for inducible cli...

echinophora platyloba d.c as a medicinal plant is used for preservation of foods and treatment of many diseases in different regions of iran. the present study was undertaken to determine the chemical composition and investigation of the antibacterial effects of essential oil as well as methanol extract from aerial part of echinophora platyloba d.c against s. aureus, l. monocytogenes, s. thyphi...

Analogs of furanonaphthoquinone (FNQ) from Tecoma ipe Mart had MICs ranging from 1.56 to 25 microg/ml against gram-positive bacteria. FNQ showed significantly lower MICs against methicillin-resistant Staphylococcus aureus than against methicillin-sensitive S. aureus. FNQ inhibited Helicobacter pylori with an MIC of 0.1 microg/ml. Fungi, including pathogenic species, were sensitive to FNQ with M...

The penicillin-binding proteins (PBPs) are a set of enzymes that participate in bacterial peptidoglycan assembly. The absolute numbers of each PBP were determined by direct measurement and have been reported for two Staphylococcus aureus strains, RN4220 (methicillin-sensitive S. aureus) and RN450M (methicillin-resistant S. aureus). From the specific activity of the labeled penicillin and the ab...

Betaines were evaluated as potential antistaphylococcal agents for urinary tract infections. Staphylococcus aureus accumulated all tested betaines except trigonelline. S. aureus transport systems were less sensitive to carbon chain length than those of Escherichia coli. Betaines were accumulated in the absence of osmotic stress, and 10-fold more in hyperosmotic medium. Most betaines increased t...

Oxazolidinone-resistant mutants of Staphylococcus aureus, isolated with a spiral plating technique, had a 16-fold higher MIC (2 versus 32 microg/ml) of eperezolid when compared to the parental sensitive strain. Eperezolid inhibited in vitro protein translation with 50% inhibitory concentrations of 30 microM for the oxazolidinone-sensitive S30 extract and 75 microM for the resistant extract. Exp...

We investigated Staphylococcus aureus contamination of the hand rims and handles of wheelchairs for common use on hospital wards by wiping with gauze. Examination of the hand rims of a total of 20 wheelchairs revealed methicillin-sensitive S. aureus (MSSA) and/or methicillin-resistant S. aureus (MRSA) on 17 wheelchairs (85.0%), and MRSA on 11 (55.0%). The mean ± SD (range) density of MRSA conta...

Ethanolic leaf extracts of 5 medicinal plants traditionally used in medicine were studied for their antimicrobial activity against antibiotic-susceptible and resistant Staphylococcus aureus strains isolated from different clinical samples. The antimicrobial activity of plant extracts was determined by using agar well diffusion method. The plant extracts showed varied levels of antimicrobial act...