background: radiation therapy is an effective method used for treatment of many types of cancers. however, this method can cause unwanted side effects such as bone marrow suppression. in this study, the effect of oral administration of biogenic selenium nanoparticles (senps) on total and differentiated white cells profile of balb/c mice exposed to x-ray radiation was investigated and compared w...

As an effective antiviral agent, the clinical application of oseltamivir (OTV) is limited by the appearance of drug-resistant viruses. Due to their low toxicity and excellent activity, the antiviral capabilities of selenium nanoparticles (SeNPs) has attracted increasing attention in recent years. To overcome the limitation of drug resistance, the use of modified NPs with biologics to explore no...

Abstract Cancer-fighting needs more effective and targeted drugs, desirably with least side-effects from natural bases. The assessment synergistic actions of multiple anticancer drug candidates were investigated. Fucoidan (Fu) was extracted Sargassum cinereum , which attained the Saudi Red-Sea coast. extract Ganoderma lucidum or Reishi mushroom (Re) achieved, intermixed Fu solution, they used f...

Small ubiquitin like modifier (SUMO) specific proteases (SENPs) are cysteine proteases that carry out the proteolytic processing of SUMO from its pro form as well as the deconjugation of SUMO from substrate proteins. SENPs are attractive targets for drug discovery due to their crucial role in the development of various diseases. However, the SENPs inhibitor discovery efforts were limited, and o...

SENPs [Sentrin/SUMO (small ubiquitin-related modifier)-specific proteases] include proteases that activate the precursors of SUMOs, or deconjugate SUMOs attached to target proteins. SENPs are usually assayed on protein substrates, and for the first time we demonstrate that synthetic substrates can be convenient tools in determining activity and specificity of these proteases. We synthesized a g...

This study presents an ecologically conscious methodology for synthesizing tea polypeptides-selenium nanoparticles (TP-SeNPs) exhibiting antioxidant and antibacterial properties, utilizing polypeptides (TP). Proteins were extracted from leaves using alkali extraction-acid precipitation method, response surface (RSM) was employed to optimize the preparation processes both TP TP-SeNPs. The extrac...

Selenium nanoparticles (SeNPs) are specific form of this element that has recently become the subject numerous research, especially in field biomedicine. Several synthesis procedures for obtaining SeNPs have been developed so far, among those including reduction selenium salts most frequently used. In work, it is examined effect two stabilizing agents on morphology, size, and crystallinity obta...

Sentrin specific proteases (SENPs) are responsible for activating and deconjugating SUMO (Small Ubiquitin like MOdifier) from target proteins. It remains difficult to study this posttranslational modification due to the lack of reagents that can be used to block the removal of SUMO from substrates. Here, we describe the identification of small molecule SENP inhibitors and active site probes con...