Proper morphogenesis of inner ear semicircular canals requires precise regulation of cellular proliferation, epithelial-to-mesenchymal transition, and fusion of epithelial plates. Epigenetic regulation of these processes is not well understood, but is likely to involve chromatin remodeling enzymes. CHD7 is a chromodomain-containing, ATP dependent helicase protein that is highly expressed in the...

CONCLUSION Additional research is needed to validate the importance of the video head impulse tests (vHIT), but it provides an important contribution to the evaluation of anterior and posterior semicircular canal disorders. OBJECTIVES To share observations of the vHIT test in clinical neurotology and to discuss the significance of the study findings. METHODS This study comprised 200 patient...

Imaging of the cochlea and internal auditory canals are increasingly important nowadays because of the growing number of cochlear implants being performed throughout the world. We report a case of a 4-year-old boy who was born deaf and was being evaluated in our service for possible cochlear implantation. Audiometry disclosed profound bilateral deafness. The magnetic resonance imaging revealed ...

Studies have reported a functional link between the arc size of the semicircular canals and locomotor agility across adult primates. However, canal size is spatially interlinked with the subarcuate fossa. This fossa can house the petrosal lobule of the paraflocculus, which also plays a role in coordinating head and eye movements. Consequently, it could be that it is the size of the petrosal lob...

The function of the three semicircular canals of the vertebrate labyrinth which are situated in three approximately perpendiailar planes is the detection of angular accelerations. Because of the inertia of the liquid (endolymph) in the membranous canal a fluid current is set up in the endolymph by angular acceleration. This endolymph current displaces the cupula in the ampulla. The cupula-senso...

• The vestibular system primarily drives reflexes to maintain stable vision and posture. • By modulating the non-zero baseline firing of vestibular afferent nerve fibers, semicircular canals encode rotation of the head, and otolith organs encode linear acceleration and tilt. • Stimulation of a semicircular canal produces eye movements in the plane of that canal. • A semicircular canal normally ...

BACKGROUND AND OBJECTIVES Benign paroxysmal positional vertigo (BPPV) generally involves a single semicircular canal (single canal BPPV) but it has been reported that more than one semicircular canal on either the same or the opposite side can be involved in 6.8-20% of the cases (multiple canal BPPV). In this study, the clinical characteristics of multiple canal BPPV were analyzed and compared ...