In rats, the respective contribution of the thyroid and peripheral tissues to the pool of T3 remains unclear. Most, if not all, of the circulating T3 produced by extrathyroidal sources is generated by 5'-deiodination of T4, catalyzed by the selenoenzyme, type I iodothyronine 5'-deiodinase (5'D-I). 5'D-I in the liver and kidney is almost completely lost in selenium deficiency, resulting in a mar...

Selenium-accumulating plants such as Brassica juncea (Indian mustard) concentrate the element in plant shoots and roots. Such behavior may provide a cost-effective technology to clean up contaminated soils and waters that pose major environmental and human health problems (phytoremediation). Such ability to transform selenium into bioactive compounds has important implications for human nutriti...

Previous studies have shown that transcription factors, API and NFkB exert important roles in the process by which selenium regulates spermatogenesis. Glutathione, an intracellular thiol, acts as a source of reducing power and aids in maintenance of the cellular redox status. The activities of selenium are closely related to the availability of glutathione. Presently, mouse testicular cells wer...

BACKGROUND Brazil nuts provide a rich natural source of selenium, yet no studies have investigated the bioavailability of selenium in humans. OBJECTIVE We investigated the efficacy of Brazil nuts in increasing selenium status in comparison with selenomethionine. DESIGN A randomized controlled trial was conducted with 59 New Zealand adults. Participants consumed 2 Brazil nuts thought to prov...

Abstract Atmospheric deposition is a major source of the nutrients sulfur and selenium to agricultural soils. Air pollution control cleaner energy production have reduced anthropogenic emissions selenium, which has led lower atmospheric fluxes these elements. Here, we use global aerosol-chemistry-climate model map recent (2005–2009) deposition, project future (2095–2099) changes under two socio...