نتایج جستجو برای: selective cox 2 inhibitors

تعداد نتایج: 2821211  

2013
Carla J. Gargallo Angel Lanas

Evidence shows that suboptimal adherence to gastroprotective agents (GPAs) decreases the beneficial effects on the risk of upper gastrointestinal (GI) complications (UGIC) associated with the use of traditional non steroidal anti-inflammatory drugs (NSAIDs) [1]. There is less evidence about the role of GPA adherence for lowering the risk of UGIC in selective cyclooxygenase (COX)-2 inhibitors us...

SK Kulkarni SSV Padi

Despite the important role of both cyclooxygenase (COX) isoforms (i.e. COX-1 and COX-2) in maintenance of hypersensitivity following peripheral nerve injury, their role in the development of neuropathic pain is not clear. The present study was undertaken to determine the effect of COX inhibitors to address the potential role of COX isozymes in the development of neuropathic pain in rats after c...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2000
A S Kalgutkar B C Crews S W Rowlinson A B Marnett K R Kozak R P Remmel L J Marnett

All nonsteroidal antiinflammatory drugs (NSAIDs) inhibit the cyclooxygenase (COX) isozymes to different extents, which accounts for their anti-inflammatory and analgesic activities and their gastrointestinal side effects. We have exploited biochemical differences between the two COX enzymes to identify a strategy for converting carboxylate-containing NSAIDs into selective COX-2 inhibitors. Deri...

Journal: :Oncology reports 2014
Teruyoshi Saito Dai Tamura Ryuji Asano

Cyclooxygenase-2 (COX-2) is a key enzyme for converting arachidonic acids to prostanoids, which are known to be induced during inflammation and cancer initiation. Previously, it has been reported that COX inhibitors, such as aspirin, reduce the incidence of human colorectal cancer; therefore, it is widely believed that COX-2 is a potential therapeutic and chemoprevention target for several type...

2003
Graeme J. Hankey John W. Eikelboom

Background and Summary—Selective cyclooxygenase (COX)-2 inhibitors are increasingly being used in place of “conventional” nonsteroidal anti-inflammatory drugs (NSAIDs). This is because they are just as effective as NSAIDs in relieving arthritic pain and yet less gastrotoxic. However, the cardiovascular safety of selective COX-2 inhibitors has been questioned because they selectively reduce pros...

SK Kulkarni SSV Padi

Despite the important role of both cyclooxygenase (COX) isoforms (i.e. COX-1 and COX-2) in maintenance of hypersensitivity following peripheral nerve injury, their role in the development of neuropathic pain is not clear. The present study was undertaken to determine the effect of COX inhibitors to address the potential role of COX isozymes in the development of neuropathic pain in rats after c...

2017
Mohammad Bakhriansyah Patrick C Souverein Anthonius de Boer Olaf H Klungel

PURPOSE To assess the risk of gastrointestinal perforation, ulcers, or bleeding (PUB) associated with the use of conventional nonsteroidal anti-inflammatory drugs (NSAIDs) with proton pump inhibitors (PPIs) and selective COX-2 inhibitors, with or without PPIs compared with conventional NSAIDs. METHODS A case-control study was performed within conventional NSAIDs and/or selective COX-2 inhibit...

Journal: :BMJ 2006
Harald E Vonkeman Jacobus R B J Brouwers Mart A F J van de Laar

Concern is growing about an increased risk of thrombotic events (including myocardial infarction and stroke) during the use of non-steroidal antiinflammatory drugs (NSAIDs), in particular the so called selective cyclo-oxygenase-2 (COX 2) inhibitors. Although clinical trials give conflicting results with respect to the incidence of vascular events, increasing evidence shows that a class effect m...

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