PURPOSE To clinically and genetically characterize a distinct phenotype of congenital megalocornea (horizontal corneal diameter ≥13 mm) with secondary glaucoma from spherophakia and/or ectopia lentis during childhood in affected Saudi families. METHODS Clinical exam, homozygosity scan, and candidate gene analysis. RESULTS From 2005 to 2010, eight affected individuals from three consanguineo...

PURPOSE To compare outcomes in exfoliation glaucoma versus primary open-angle glaucoma (POAG) after ab interno trabeculectomy alone (Trabectome) or in combination with cataract surgery and intraocular lens (IOL) implantation. SETTING Trabectome Study Group institutions. DESIGN Prospective nonrandomized cohort study. METHODS Outcomes included intraocular pressure (IOP), glaucoma medication...

OBJECTIVES (i) To determine the prevalence and pattern of glaucomas presented to Nepal Eye Hospital for strategic planning. (ii) To know the most common attributable factors giving rise to secondary glaucoma. (iii) To know the incidence of Glaucoma blindness. MATERIALS AND METHODS A retrospective hospital based analysis of medical records of patients attending Nepal Eye Hospital Glaucoma clin...

The two main issues that concern glaucoma patients before and after penetrating keratoplasty and posterior lamellar procedures and patients that develop glaucoma after surgery are the risks of graft failure and the aggravation of the glaucoma. Failure of the corneal graft may require regrafting, which increases the risk of developing or aggravating glaucoma, while uncontrolled glaucoma may resu...

Transient or permanent elevation of intraocular pressure (IOP) is a common complication following vitreoretinal surgery. Usually secondary glaucoma, which develops after scleral buckling procedures, or pars plana vitrectomy for repair of rhegmatogenous retinal detachment, is of multifactorial origin. It is essential, for appropriate management, to detect the cause of outflow obstruction. An exa...

BACKGROUND Glaucoma is the leading cause of irreversible blindness worldwide. There tends to be a lower reporting of glaucoma in Africa compared to other blinding conditions in global burden data. Research findings of glaucoma in Nigeria will significantly increase our understanding of glaucoma in Nigeria, in people of the West African diaspora and similar population groups. We determined the p...

Noteworthy heterogeneity exists in the rare diseases associated with childhood glaucoma. Primary congenital glaucoma is mostly sporadic; however, 10% to 40% of cases are familial. CYP1B1 gene mutations seem to account for 87% of familial cases and 27% of sporadic cases. Childhood glaucoma is classified in primary and secondary congenital glaucoma, further divided as glaucoma arising in dysgenes...

The records of all the glaucoma patients seen at the General Hospital Kuala Lumpur over a five year period were analysed. The racial, age and sex distribution of patients with primary open angle glaucoma and primary angle closure glaucoma was determined. The causes of secondary glaucoma were analysed. As no previous records of glaucoma statistics are available in Malaysia, it is hoped that thes...

Congenital syphilis is caused by Treponema pallidum infection through the placenta in the embryonic stage and causes ophthalmic symptoms in childhood and adulthood. Ocular involvement of congenital syphilis consists of interstitial keratitis, anterior uveitis, acute iridocyclitis, chorioretinitis, perivasculitis, optic neuritis and secondary glaucoma. Interstitial keratitis and anterior uveitis...