A very flexible synthesis of non proteinogenic amino acids and an effective ring closure method for formation of macrolactams were elaborated. These methods are prerequisite for economical synthesis of cyclopeptides . The total syntheses of several cyclopeptides which had been isolated from plants, fungi and lower sea animals are described.

The regulatory role of miRNA in gene expression is an emerging hot new topic in the control of hypometabolism. Sea cucumber aestivation is a complicated physiological process that includes obvious hypometabolism as evidenced by a decrease in the rates of oxygen consumption and ammonia nitrogen excretion, as well as a serious degeneration of the intestine into a very tiny filament. To determine ...

makrān or mukrān was a vast region in the south eastern plateau of iran, whose border extended from kerman on the west to sind on the east. this extended area was limited to sistan on the north and makrān sea (sea of oman) on the south. makrān, mākā, mīkā, mukrān, gidruziyā, zhidruziyā, etc. are the names applied to this region in different historical periods. the expanse of this region’s borde...

Enterotoxins with superantigenic properties secreted during systemic Staphylococcus aureus infection are responsible for toxic shock. We show that intranasal administration of staphylococcal enterotoxin A (SEA), but not a recombinant SEA lacking superantigenic activity, protected mice against lethal systemic SEA challenge. Protection was superantigen specific since intranasal exposure to SEA wo...

Wild California sea lions (Zalophus californianus) have an unusually high prevalence of neoplasms (18% of stranded dead adults) and high levels of contaminants. The contribution of organochlorine (OC) tissue burdens to the probability of sea lions dying from carcinoma was explored using a logistic regression model. Levels of PCBs and DDTs were determined in blubber of sea lions diagnosed with m...

Exposure of neonatal mice to appropriate, cross-reactive Id (CRI) preparations alters immune responsiveness, ameliorates pathology, and prolongs survival of animals upon subsequent Schistosoma mansoni infection. However, because schistosome infections profoundly affect host immunobiology, which responses are effected by neonatal Id exposure alone and which responses are influenced by infection ...

Infectious diseases have been implicated as a cause of high rates of adult mortality in southern sea otters. Exposure to environmental contaminants can compromise the immuno-competence of animals, predisposing them to infectious diseases. In addition to organic pollutants, certain trace elements can modulate the immune system in marine mammals. Nevertheless, reports of occurrence of trace eleme...

Nowadays, a noticeable part of the relations among the states turn around the environment protection. Therefore, the right for ever-creasing use of the existing resources of this inland sea cannot be exclusive to any Caspian State and the aftermath involves all countries of this basin. In this respect, agreement on political border and boundaries with the Caspian Sea?s ecosystem is a difficul...