OBJECTIVES Based on the previous reports, silymarin can suppress nitric oxide, prostaglandin E2 (PGE2), leukotrienes, cytokines production, and neutrophils infiltration. Regarding the fact that inflammation plays an important role in neuropathic and formalin-induced pain, it was assumed that silymarin could reduce pain. The present study investigates the analgesic effects of silymarin in chemic...

The purpose of this study was to investigate the effect of electrical stimulation on sciatic nerve regeneration and functional recovery of target muscles. Mice were randomly divided into 3 groups: ligated without electrical stimulation, ligated with electrical stimulation and control (non-ligated). The unilateral peripheral mononeuropathy was produced on the right hind limb. Sciatic nerve was t...

G-protein receptor 84 (GPR84) is an orphan receptor that is induced markedly in monocytes/macrophages and microglia during inflammation, but its pathophysiological function is unknown. Here, we investigate the role of GPR84 in a murine model of traumatic nerve injury. Naive GPR84 knock-out (KO) mice exhibited normal behavioral responses to acute noxious stimuli, but subsequent to partial sciati...

In this study the behavioral effects of sectioning the saphenous nerve at the time of application of the loose ligature and the effect of a selective ?1-adrenergic antagonist for two weeks after tying ligatures was examined. Male Sprague-Dawley rats were used in this study. Animals were divided into six groups: Sham-operated, sciatic nerve ligation (CCI), saphenous nerve section (Saph), CCI + S...

The hindpaws of 1-d-old rats were partially denervated by transection and ligation of the sciatic nerve. Following growth to adulthood, the topographical organization of the hindpaw representation in primary somatosensory (S-I) cortex was studied with neurophysiological mapping techniques and compared to the organization of previously studied normal adult rats and adult rats that had sciatic tr...

In this study the behavioral effects of sectioning the saphenous nerve at the time of application of the loose ligature and the effect of a selective ?1-adrenergic antagonist for two weeks after tying ligatures was examined. Male Sprague-Dawley rats were used in this study. Animals were divided into six groups: Sham-operated, sciatic nerve ligation (CCI), saphenous nerve section (Saph), CCI + S...

objective(s):  the aim of this study was to evaluate the final outcome of nerve regeneration across the eggsell membrane (esm) tube conduit in comparison with autograft. materials and methods: thirty adult male rats (250-300 g) were randomized into (1) esm conduit, (2) autograft, and (3) sham surgery groups. the eggs submerged in 5% acetic acid. the decalcifying membranes were cut into four pie...

Pharmacotherapy of neuropathic pain is still challenging. Our earlier work indicated an analgesic effect dimethyl trisulfide (DMTS), which was mediated by somatostatin released from nociceptor nerve endings acting on SST4 receptors. Somatostatin release occurred due to TRPA1 ion channel activation. In the present study, we investigated DMTS in evoked partial ligation sciatic mice. Expression mR...

repairing the damaged nerves caused by physical injury (trauma), is one of the major challenges facing modern medical sciences. evening primrose oil (epo) extraction of oenothera biennis seed that enriches with omega-6,γ-linoleic acid and linoleic acid that they have essential role in myelination and neural membrane structure. the aim of this study was to evaluate the functional recovery of sci...