All the authors declare that there is no potential conflict of interest referring to this article. Citation: Jatte FG, Mazzer N, Monte-Raso VV, Leoni ASL, Barbieri CH. Therapeutic ultrasound on the spinal cord accelerates regeneration of the sciatic nerve in rats. Acta Ortop Bras. [online]. 2011; 19(4):213-8. Available from URL: http://www.scielo.br/aob. ABSTRACT Objective: To study the effects...

The rat sciatic nerve is a well-established animal model for the study of recovery from peripheral nerve injuries. Footprint analysis is the most widely used non-invasive method of measuring functional recovery after injury in this model. We describe a new alternative video analysis of standing (or static footprint video analysis) to assess functional loss following injury to the rat sciatic ne...

BACKGROUND Olfactory ensheathing glia (OEG) has been shown to have a neuroprotective effect after being transplanted in rats with spinal cord injury. This study was conducted to determine the possible beneficial results of olfactory mucosa transplantation (OMT) which is a source of OEG on functional recovery and axonal regeneration after transection of the sciatic nerve. METHODS In this study...

Objective- The objective was to assess local effect of brain derived neurotrophic factor (BDNF) on functional recovery of peripheral nerve in rat sciatic nerve transection model. Design- Experimental study. Animals- Sixty male healthy white Wistar rats Procedures- The animalswere randomized into four experimental groups of 15 animals each: In sham-operated group (SHAM), sciatic nerve was exp...

Peripheral nerve injury (PNI) is a common disease that often results in axonal degeneration and the loss of neurons, ultimately leading to limited nerve regeneration and severe functional impairment. Currently, there are no effective treatments for PNI. In the present study, we transduced conserved dopamine neurotrophic factor (CDNF) into mesenchymal stem cells (MSCs) in collagen tubes to inves...

The aim of this study was to evaluate the effects of exercise in the aquatic environment, performed before and/or after sciatic nerve compression in Wistar rats on morphological and functional parameters. Twenty-five Wistar rats were divided into the following groups: control (C), lesion (L), trained+lesion (TL), lesion+exercise (LE), and training+lesion+exercise (TLE), who underwent right scia...

  Abstract   Background : Although, different studies on end-to-side nerve repair, results are controversial. The importance of this method in case is unavailability of proximal nerve. In this method, donor nerves also remain intact and without injury. In compare to other classic procedures, end-to-side repair is not much time consuming and needs less dissection. Overall, the previous studies i...

OBJECTIVES We investigated the effects of treadmill training (10 weeks) on hindlimb motor function and nerve morphometric parameters in diabetic rats submitted to sciatic nerve crush. MATERIALS AND METHOD Wistar rats (n = 64) were divided into the following groups: non-diabetic; trained non-diabetic; non-diabetic with sciatic nerve crush; trained non-diabetic with sciatic nerve crush; diabeti...

Cyclin-dependent kinase 5 (CDK-5) appears to play a significant role in peripheral nerve regeneration as CDK-5 inhibition retards nerve regeneration following nerve crush. Anti-inflammatory drug acetyl salicylic acid elevates CDK-5 and reduces ischemia - reperfusion injury in cultured neurons. In this study we have evaluated the effect of acetyl salicylic acid on functional recovery following s...