An evaluation study on reversibility of Schistosoma mansoni induced periportal fibrosis (PF) morbidity following treatment with praziquantel, 40mg/kg body weight after one year, was carried out in Rhino Camp and Obongi all are West Nile districts in northern Uganda. To assess the reversibility of Schistosoma (S) mansoni induced PFs morbidity following treatment with praziquantel, 40mg/kg body w...

The present study describes a real-time PCR approach with high resolution melting-curve (HRM) assay developed for the detection and differentiation of Schistosoma mansoni and S. haematobium in fecal and urine samples collected from rural Yemen. The samples were screened by microscopy and PCR for the Schistosoma species infection. A pair of degenerate primers were designed targeting partial regi...

BACKGROUND Numerous factors may influence Schistosoma infection intensity and prevalence within endemic communities, including exposure-related factors such as local environment and behaviour, and factors relating to susceptibility to infection such as immunology and genetics. While animal studies performed in the laboratory can be tightly controlled, human populations are highly heterogeneous,...

Studies in African countries have shown an association between irrigation projects and the spread of schistosomiasis mansoni and haematobium. The aim of this study was to investigate the potential association between irrigation levels and the occurrence and spread of Schistosoma mansoni infection in the State of Bahia. Two forms of irrigation were developed in the State of Bahia: the first is c...

This paper reports reduction on the reproductive capacity of female mice infected with Schistosoma mansoni, either in the acute phase or in the chronic one of the disease. This decrease in the reproductive capacity was highly significant (93.3% and 86.7%, for the acute and chronic phases, respectively).

There is an omission in the Acknowledgments section. Please see the corrected Acknowledgments here: We thank Prof. J. Webster, together with Drs. Polydor Ngoy Mutombo, Moussa Sacko and Charlotte Gower, for access to the raw microsatellite data of Kokry-Bozo (Mali), and the Schistosomiasis Collection team at the Natural History Museum in London (SCAN) for providing S.mansoni worms. We are gratef...

Etiologic Agent Schistosomiasis is a disease caused by parasitic worm of genus Schistosoma [1]. It belongs to phylum Platyhelminthes, class Trematoda and genus Schistosoma [2]. Most human infections are caused by the three species: S. mansoni, S. haematobium, and S. japonicum [3]. There are two more species S. intercalatum and S. mekongi known to cause Schistosomiasis [3]. The most infections c...

A vaccine against schistosomiasis would contribute significantly to reducing the 3-70 million disability-adjusted life years lost annually to the disease. Towards this end, inoculation with the large extracellular loop (EC-2) of Schistosoma mansoni tetraspanin-2 protein (Sm-TSP-2) has proved effective in reducing worm and egg burdens in S. mansoni-infected mice. The EC-2 loop of Schistosoma jap...