Was ist mit Nachhaltigkeit eigentlich gemeint? Salopp gesprochen, geht es für uns alle darum, nicht weiter so zu tun, als hätten wir eine zweite Welt als ständige Notfallreserve im Kofferraum. Wissenschaftlicher formuliert heißt das: Die konventionelle, materialund energieintensive Wirtschaftsweise ist nicht zukunftsfähig. Wir leben in unserem „Raumschiff Erde“ über unsere Verhältnisse, weil Ro...

Across species, the fi tness costs of parasitic infection have been a major force shaping host adaptations to avoid infection (Hart 2009 ; Schmid-Hempel 2003 ; Sheldon and Verhulst 1996 ), diminish the cost of infection (Minchella 1985 ; Råberg et al. 2009 ), and even advertise resistance to infection to possible mates (Hamilton and Zuk 1982 ; Moller 1990 ). These adaptations, in turn, have sha...

Nearly 40% of farmland in the United States is rented or leased from agricultural landowners (USDA NASS 2015), majority whom are nonoperator (NOLs). NOLs increasingly identified as a group who should be included when discussing environmental issues on lands. Yet, and what we know about them terms conservation practices limited. Comprehensive, national-scale data have been provided only three ti...

F. Risse, C. Fink, S. Ley, H-U. Kauczor, L. R. Schad Department of Medical Physics in Radiology, Deutsches Krebsforschungszentrum, Heidelberg, Germany, Department of Radiology, Deutsches Krebsforschungszentrum, Heidelberg, Germany Introduction Contrast-enhanced 3D MRI offers the capability to assess lung perfusion non-invasively and without radiation exposure [1]. Recently, parallel imaging tec...

It is well recognized that compared with men, women have better ultra-endurance capacity, oxidize more fat during endurance exercise, and are more resistant to fat oxidation defects i.e. diet-induced insulin resistance. Several groups have shown that the mRNA and protein transcribed and translated from genes related to transport of fatty acids into the muscle are greater in women than men; howe...

The forkhead gene family, named after the founding gene member in Drosophila, is characterized by a unique DNA-binding domain. This so-called forkhead box encodes a winged-helix DNA-binding motif, the name of which describes the structure of the domain when bound to DNA. The three Fox (forkhead box) group A genes, Foxa1, Foxa2 and Foxa3, are expressed in embryonic endoderm, the germ layer that ...

BACKGROUND The effects of diet-induced obesity on skeletal muscle function are largely unknown, particularly as it relates to changes in oxidative metabolism and morphology. PRINCIPAL FINDINGS Compared to control fed mice, mice fed a high fat diet (HFD; 60% kcal: fat) for 8 weeks displayed increased body mass and insulin resistance without overt fasting hyperglycemia (i.e. pre-diabetic). Hist...

A cross-sectional audit of patient charts was conducted in the Robert Schad Naturopathic Clinic (RSNC), the largest naturopathic teaching clinic in North America, to assess the management of essential hypertension (EH) compared to recommendations made by the Canadian Hypertension Education Program (CHEP). Objectives of this study included the assessment of adherence to 2012 CHEP guidelines, a s...

Hyperinsulinism (HI) is the leading cause of persistent hypoglycemia in children, which if unrecognized may lead to development delays and permanent neurologic damage. Prompt recognition and appropriate treatment of HI are essential to avoid these sequelae. Major advances have been made over the past two decades in understanding the molecular basis of hyperinsulinism and mutations in nine genes...