CD30 is a costimulatory receptor on activated lymphocytes and a number of human lymphoma cells. Specific ligation of membrane-bound CD30 or cellular stimulation by PMA results in a metalloproteinase-mediated down-regulation of CD30 and release of its soluble ectodomain (sCD30). In this report, it is demonstrated that PMA-induced CD30 cleavage from Karpas 299 cells was mediated by a membrane-anc...

background: normal pregnancy is thought to be dependent on th2 deviation, while recurrent pregnancy loss (rpl) and pre-eclampsia (pe) appear to be biased toward the th1 immune response. it is believed that the soluble form of cd30 (scd30) is an index of th2 immune response or modulator of th1/th2 responses. objective: the aim of this study was determination of the scd30 level in rpl and pe pati...

BACKGROUND AND OBJECTIVE Measles virus infection (MVI) has been reported to be characterized by an imbalanced Th(1/2)-type cytokine profile. CD30 has been proposed as a receptor preferentially associated with the Th(0/2)-type cytokine pattern. The aim of this study was therefore to define the peripheral T lymphocyte cytokine profile and to test which CD30 expression pattern it was associated wi...

background: primary malignant bone tumors are heterogeneous groups of neoplasms, which affect mainly children and adolescents. the most common types are osteosarcoma, ewing sarcoma and chondrosarcoma. elevation of scd30 and scd40l has been observed in lymphoma, leukemia and autoimmune disorders. objective: to evaluate serum concentrations of scd30 and scd40l in patients with primary malignant b...

A nested case-control study was conducted to examine the association between host immune status, as characterized by serum immune marker levels, and the development of hepatocellular carcinoma (HCC) up to 8 years later in persons with chronic hepatitis C virus (HCV) infection. Cases (n = 39) and matched controls (n = 117) were selected from participants of the Town C HCV Study in Japan between ...

Co-signaling molecules are responsible for full T-cell activation after solid organ transplantation. Their increased expression can lead to the release of a soluble form that can modulate the immune response post-transplantation. We analyzed the presence of co-signaling molecules (sCD30, sCD40, sCD137, sCTLA-4, sCD80, sCD28, sCD40L, sPD-1, and sPD-L1) in serum from kidney-transplanted patients ...

Plasma levels of cytomegalovirus (CMV)–specific immunoglobulin G (IgG), soluble (s) CD30, sCD26 (dipeptidyl peptidase IV [DPP IV]) enzyme activity, and tumor necrosis factor receptor–I (TNFR-I) were assessed in human immunodeficiency virus (HIV)– infected patients who experienced CMV retinitis (CMVR) as an immune restoration disease (IRD) during their first 6 months of highly active antiretrovi...