In type 1 Gaucher disease, decreased activity of glucocerebrosidase results in accumulation of glucosylceramide in macrophages. Infiltration of liver, spleen and bone marrow by lipid-laden macrophages leads to hepatosplenomegaly, bone lesions and cytopenia. These abnormal macrophages may produce and release macrophage derived factors and cytokines, which could contribute to the pathophysiology ...

OBJECTIVE To compare microbial translocation and its biomarkers in HIV-1-infected African and White patients of the Liège AIDS Reference Center. DESIGN The study is based on a cross-sectional dataset of HIV-infected patients treated at the Liège AIDS Reference Center. Groups of white and African patients have been randomly selected to be identical for sex, age and duration of treatment. MET...

Soluble (s) CD14, a marker for monocyte/macrophage activation and a mediator of bacterial lipopolysaccharide (LPS) action, was elevated in serum from human immunodeficiency virus type 1 (HIV- 1)-infected individuals (n = 92) compared with seronegative controls. The highest levels were found in patients with advanced clinical and immunological disease. Patients with ongoing clinical events had s...

BACKGROUND Early childhood caries (ECC) is a severe type of dental caries affecting infants and pre-school children. Because of the infectious nature of the disease, the immunologic response by the host plays an essential role in its development. OBJECTIVE This study investigated the association between the presence of salivary sCD14 and ECC. METHODS This study was carried out on 40 healthy...

Downlo rgy history has been consistently inversely associated with glioma risk. Two serologic markers, soluble (sCD23) and soluble CD14 (sCD14), are part of the innate and adaptive humoral immune systems and late allergic responses in opposite directions, with sCD23 enhancing and sCD14 blunting inflammatory ses. We measured sCD23 and sCD14 in serum from blood that was drawn at a single time poi...

Host proinflammatory responses to minute amounts of endotoxins derived from many Gram-negative bacteria require the interaction of lipopolysaccharide-binding protein (LBP), CD14, Toll-like receptor 4 (TLR4) and MD-2. Optimal sensitivity to endotoxin requires an ordered series of endotoxin-protein and protein-protein interactions. At substoichiometric concentrations, LBP facilitates delivery of ...

Downlo rgy history has been consistently inversely associated with glioma risk. Two serologic markers, soluble (sCD23) and soluble CD14 (sCD14), are part of the innate and adaptive humoral immune systems and late allergic responses in opposite directions, with sCD23 enhancing and sCD14 blunting inflammatory ses. We measured sCD23 and sCD14 in serum from blood that was drawn at a single time poi...

background: early childhood caries (ecc) is a severe type of dental caries affecting infants and pre-school children. because of the infectious nature of the disease, the immunologic response by the host plays an essential role in its development. objective: this study investigated the association between the presence of salivary scd14 and ecc. methods: this study was carried out on 40 healthy ...

BACKGROUND AIMS Liver inflammation is a risk factor for the progression of nonalcoholic fatty liver disease (NAFLD). However, the diagnosis of liver inflammation is very difficult and invasive liver biopsy is still the only method to reliably detect liver inflammation. We previously reported that overexpression of CD14 in Kupffer cells may trigger the progression to nonalcoholic steatohepatitis...

We investigated the expression of membrane-bound CD14 (mCD14) on monocytes and soluble CD14 (sCD14) released into the culture supernatants of peripheral blood lymphocytes (PBMC) from human immunodeficiency virus (HIV)-infected individuals. Monocytes from HIV-positive individuals exhibited both enhanced mCD14 expression and sCD14 production in the PBMC culture supernatants compared to the levels...