Materials and Methods: Since the start in June 2014 clinical and histological analyses were performed in 17 patients (6 burns and 11 trauma) treated with 2 to 4 water-jet assisted lipotransfer (WAL) procedures including a follow-up of at least 3 months. Skin biopsies were taken preoperative and after 3 months. The skin quality and scar improvement were measured by POSAS and VAS-score system and...

Materials and Methods: Since the start in June 2014 clinical and histological analyses were performed in 17 patients (6 burns and 11 trauma) treated with 2 to 4 water-jet assisted lipotransfer (WAL) procedures including a follow-up of at least 3 months. Skin biopsies were taken preoperative and after 3 months. The skin quality and scar improvement were measured by POSAS and VAS-score system and...

Background: Patients born with congenital defects of their periumbilical abdominal wall, such as gastroschisis and omphalocele, are left with scars in the center of their abdomen and no umbilicus. Attempts to recreate a neoumbilicus are challenging due to the lack of sufficient local subcutaneous tissue as well as the presence of scar. Objective: To describe a technique that allows for reconstr...

Lesion-induced scarring is a major impediment for regeneration of injured axons in the central nervous system (CNS). The collagen-rich glial-fibrous scar contains numerous axon growth inhibitory factors forming a regeneration-barrier for axons. We demonstrated previously that the combination of the iron chelator 2,2'-bipyridine-5,5'-decarboxylic acid (BPY-DCA) and 8-Br-cyclic AMP (cAMP) inhibit...

The term “cicatricial ” contains the Latin root “cicatrix,” which means “scar resulting from the formation and contraction of fibrous tissue.” (1) Historically, dermatologists have used the term cicatricial alopecia to refer to scarring alopecia caused by inflammatory disease processes such as discoid lupus erythematosus, lichen planopilaris, pseudopalade, etc. In the field of hair transplantat...

Previous wound healing studies have failed to define a role for either α1β1 or α2β1 integrin in fibroblast-mediated wound contraction, suggesting the involvement of another collagen receptor in this process. Our previous work demonstrated that the integrin subunit α11 is highly induced during wound healing both at the mRNA and protein level, prompting us to investigate and dissect the role of t...

PURPOSE Scar formation is most frequently responsible for the failure of glaucoma filtration surgery. Retinoic acids are vitamin A derivatives that play diverse roles in development, immunity, and tissue repair. The effects of the retinoic acid receptor (RAR) γ agonist R667 on the contractility of human Tenon fibroblasts (HTFs) cultured in a three-dimensional collagen gel as well as on intraocu...

Background: Conservative treatment of deep dermal or full-thickness skin defects often results in hypertrophic scars contractures; thus, compressive therapy has been used after wound closure to prevent treat scar deformities. However, contraction begins the early proliferative phase and peaks 2 weeks. We therefore attempted compression as a means conservative deep-skin evaluated its clinical ou...

Wounds in the embryo show a remarkable ability to heal quickly without leaving a scar. Previous studies have found that an actomyosin ring (purse string) forms around the wound perimeter and contracts to close the wound over the course of several dozens of minutes. Here, we report experiments that reveal an even faster mechanism which remarkably closes wounds by more than 50% within the first 3...

PURPOSE To investigate the role of Y-27632, a specific inhibitor of Rho-associated protein kinase (ROCK) in regulating human Tenon fibroblast (HTF) activities including proliferation, adhesion, contraction, migratory response, and myofibroblast transdifferentiation. Effects of Y-27632 on prevention of postoperative scar formation were also examined in a rabbit model of glaucoma filtration surge...