BACKGROUND Type 2 diabetes is associated with increased plasma concentrations of non-esterified fatty acids (NEFAs), which trigger pancreatic β-cell dysfunction and apoptosis. Only long-chain saturated NEFAs induced lipotoxicity in rat insulin-producing cells in in vitro experiments, whereas unsaturated NEFAs were not toxic. Some unsaturated NEFAs even protected against lipotoxicity. In former ...

A reaction mechanism is presented for strand break formation in poly U induced by OH radicals in N2O/O2- saturated aqueous solution based on experimental results obtained with different methods.

Hydrogenation of oils might be considered as the largest reaction in the edible oil industry. The reaction consists of the addition of hydrogen at the double bounds of fatty acids. Although for some reasons this might be considered a desirable reaction but for some others it might create problems in the food and nutrition chain circle due to the formation of saturated and trans fatty acids. Soy...

The kinetics of propionate degradation, acetate splitting, and hydrogen consumption in digesting sludge were investigated in a lab-scale digester. At natural steady-state conditions, the acetate-splitting systems in well-digested sludge were about half saturated. Propionate-degrading systems were saturated to only 10 to 15%, and hydrogen removal was less than 1% of the maximum possible rate. It...

Underground injection of gas is a common practice in the oil and gas industry. Injection into deep, brine-saturated formations is a commercially proven method of sequestering CO2 . However, it has long been known that displacement of a connate fluid by a less viscous fluid produces unstable displacement fronts with significant fingering. This fingering allows only a small fraction of the pore v...

Fragment-based lead generation has proven to be an effective means of identifying high-quality lead compounds for drug discovery programs. However, the fragment screening sets often used are principally comprised of sp(2) -rich aromatic compounds, which limits the structural (and hence biological) diversity of the library. Herein, we describe strategies for the synthesis of a series of partiall...

Oxidation of Cr(III) during sonication in carbonated aqueous solutions saturated with CCl4 leads to the quantitative formation of Cr(VI) and provides a simple and rapid method for spectrophotometric chromium determination with 1,5-diphenylcarbazide. The key to this method is the production of chlorine radicals when aqueous solution saturated with CCl4 is exposed to ultrasonic waves of 40 kHz. T...