Salicylates are widely used in the treatment of rheumatic disorders, and they have been shown to induce minor changes in renal function. One of the major mechanisms of action of salicylates is the suppression of prostaglandin synthetase activity, and in animal rnodels renal prostaglandin production is closely related to renin release and the regulation of renal blood flow. Indomethacin has been...

Kawasaki disease (KD) is a systemic vasculitis predominantly affecting young children. The disease is associated with cardiac complications such as cardiac aneurysm and thrombosis in a significant proportion of cases. Salicylates are commonly used in KD because of their antiinflammatory activity. In general, the salicylate use is limited in other childhood conditions because of potential risk o...

In cultures of mouse or chick embryo ceils several non-steroidal antiinflammatory drugs (salicylates, Ibufenac, phenylbutazone, Indomethacin, flufenamic and mefenamic acids, CI-583, and chloroquine) inhibit the multiplication of various viruses (encephalomyocarditis, Sindbis, influenza A2, Newcastle disease, herpes simplex and vaccinia). Two factors were critical for the virus inhibitory action...

performance was so deficient as to suggest a specific developmental failure. Fourteen of these children were matched for age, sex, handedness, verbal I.Q., and home and school background with an equal number of children drawn from the same sample who had shown no evidence of selective visuo-motor impairment. Both groups were followed up for a three-year period. The children with visuo-motor def...