Immune sera from convalescent patients have been shown to be effective in the treatment of patients infected with Severe Acute Respiratory Syndrome Virus (SARS-CoV) making passive immune therapy with human monoclonal antibodies an attractive treatment strategy for SARS. Previously, using Xenomouse (Amgen British Columbia Inc), we produced a panel of neutralizing Human monoclonal antibodies (HmA...

Prominin-1 (CD133) is a cholesterol-interacting pentaspan membrane glycoprotein specifically associated with plasma membrane protrusions. Prominin-1 is expressed by various stem and progenitor cells, notably neuroepithelial progenitors found in the developing embryonic brain. Here, we further investigated its expression in the murine brain. Biochemical analyses of brain membranes at early stage...

Reports of multiple distinct mitoxantrone-resistant sublines without overexpression of P-glycoprotein or the multidrug-resistance associated protein have raised the possibility of the existence of another major transporter conferring drug resistance. In the present study, a cDNA library from mitoxantrone-resistant S1-M1-80 human colon carcinoma cells was screened by differential hybridization. ...

The novel coronavirus 2019 (COVID-19) has struck more than 99 million people worldwide and had claimed 2 lives as of 23 January 2021, which affecting 221 countries/nations. Until now, the pandemic not shown signals slowing down, with no proven vaccine in sight. People are speculating on this unprecedented event. It is well documented that receptor-binding domain (RBD) viral spiked S1 glycoprote...

where on the left hand side the coefficient of XrY s is βrβs. If n is a natural number then β(X) = β([n]X), where [n]X = [n]F X is the n-series. We alse have β(X)−1 = β([−1]X), where F ([−1]X,X) = 0 = F (X, [−1]X). In fact, for any non-zero q ∈ Z(p), we can make sense of [q]X and β(X) = β([q]X). Now recall the Araki and Hazewinkel generators vn, wn ∈ BP2pn−2 for which v0 = w0 = p and vn ≡ wn mo...

In this study, 27 protein sequences of SARS-CoV-2 spike (S) glycoprotein from 23 different countries were analyzed using bioinformatics approaches. context, post-translational modifications, sequence and domain analyses, phylogenetic analysis, 3D structure analysis the proteins performed. Also, molecular docking S1 receptor-binding (SS1) with human ACE2 was conducted. It found that although all...