Although the enzymatic synthesis of S-adenosylmethionine was accomplished several years ago (l), there have, as yet, been few reports of experiments with this compound. The main reason for the paucity of data appears to be the difficulty of obtaining S-adenosylmethionine in adequate quantities at a reasonable expenditure of time and starting material. Cantoni (2) has prepared S-adenosylmethioni...

Peroxynitrite-induced relaxation of isolated vessels may involve the formation of S-nitrosothiols. This study characterized the hemodynamic effects of systemically injected peroxynitrite in pentobarbital sodium-anesthetized rats and determined whether these effects were due to the formation of S-nitrosothiols. We utilizedl-penicillamine, which attenuates the hemodynamic effects of systemically ...