Objectives: From the psychological point of view, coping strategies and attitudes have considerable effects on people’s tendency towards risky behavior, including opioid substance abuse. Dysfunctional attitudes are attitudes and beliefs that predispose the individual toward depression and psychological disorder, generally speaking. Usually, people use three types of coping strategies when...

A successful Th cell response to bacterial infections is induced by mature MHC class II molecules presenting specific Ag peptides on the surface of macrophages. In recent studies, we demonstrated that infection with the conventional vaccine Mycobacterium bovis bacillus Calmette-Guérin (BCG) specifically blocks the surface export of mature class II molecules in human macrophages by a mechanism d...

BACKGROUND & AIMS Although proteases control inflammation and pain, the identity, cellular origin, mechanism of action, and causative role of proteases that are activated during disease are not defined. We investigated the activation and function of cysteine cathepsins (Cat) in colitis. METHODS Because protease activity, rather than expression, is regulated, we treated mice with fluorescent a...

Human atherosclerotic lesions overexpress the lysosomal cysteine protease cathepsin S (Cat S), one of the most potent mammalian elastases known. In contrast, atheromata have low levels of the endogenous Cat S inhibitor cystatin C compared with normal arteries, suggesting involvement of this protease in atherogenesis. The present study tested this hypothesis directly by crossing Cat S-deficient ...

37 Animals and human beings sense and react to real/potential dangerous stimuli. However, 38 the supraspinal mechanisms relating noxious sensing and nocifensive behavior are mostly 39 unknown. The collateralization and spatial organization of interrelated neurons are 40 important determinants of coordinated network function. Here we electrophysiologically 41 studied medial medullary reticulospi...

This conceptual article describes transactional theory (R. S. Lazarus, 1999; R. S. Lazarus & S. Folkman, 1984), a framework that integrates stress, appraisal, and coping theories as they relate to how individuals react to psychologically stressful situations and/or environments. In clinical practice, this theoretical framework can be effectively utilized in the assessment, intervention, and eva...

OBJECTIVE This article introduces a Spanish version of the Generalized Expectancies for Negative Mood Regulation Scale (NMR-S) and tests the reliability and the validity of the new questionnaire. METHODS A sample of 360 students from Chile completed the NMR-S along with instruments measuring depressive symptoms, social desirability, coping, and emotion regulation. RESULTS A factor analysis ...

BACKGROUND Participation of the mentally-ill in elections promotes integration into the community. In many countries, individuals with compromised mental incompetence who have legal guardians are denied the right to vote. In Israel, mental health consumers are eligible to vote. We evaluated the capacity of psychiatric inpatients with and without legal guardians to understand the nature and effe...

OBJECTIVE To understand the role of religiousness/spirituality in coping in children with cystic fibrosis (CF). METHODS Participants were a convenience sample of 23 patients with CF, ages 5 to 12 years, and their parent(s) in an ambulatory CF clinic. The design was a focused ethnography including in-depth interviews with children and parent(s), children's drawings, and self-administered writt...

The catalytic activity of the bacterial phosphotriesterase (PTE) toward a series of chiral analogues of the chemical warfare agents sarin and soman was measured. Chemical procedures were developed for the chiral syntheses of the S(P)- and R(P)-enantiomers of O-isopropyl p-nitrophenyl methylphosphonate (sarin analogue) in high enantiomeric excess. The R(P)-enantiomer of the sarin analogue (k(cat...