Chemotherapy is a common treatment for leukemia. Ruthenium complexes have shown potential utility in chemotherapy and photodynamic therapy. The identification of new chemotherapeutics agents is critical for further progress in the treatment of leukemia. Ruthenium complexes generally have lower toxicities compared to cisplatin attributed to their specific accumulation in cancer tissues. Based on...

Ruthenium(III) complexes are promising candidates for anticancer drugs, especially the clinically studied indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019) and its analogue sodium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (NKP-1339). Several studies have emphasized the likely role of human serum proteins in the transportation and accumulation of ruthenium(III) comple...

We present a case study where we use automated formal analysis to reason about problem-frame concerns. The descriptions of the problem domains, machine and requirements are written in the Alloy language. We show that an evaluation of results and counterexamples provided by a model finder can reveal useful information that can help remove inconsistencies as well as composition errors.

Magnetically recyclable catalysts with magnetic nanoparticles (MNPs) are becoming a major trend towards sustainable catalysts. In this area, recyclable supported ruthenium complexes and ruthenium nanoparticles occupy a key place and present great advantages compared to classic catalysts. In this micro-review, attention is focused on the fabrication of MNP-supported ruthenium catalysts and their...

An efficient one-pot method for the enzyme- and ruthenium-catalyzed enantioselective transformation of α-allenic alcohols into 2,3-dihydrofurans has been developed. The method involves an enzymatic kinetic resolution and a subsequent ruthenium-catalyzed cycloisomerization, which provides 2,3-dihydrofurans with excellent enantioselectivity (up to >99 % ee). A ruthenium carbene species was propos...

Ruthenium complexes are considered as potential replacements for platinum compounds in oncotherapy. Their clinical development is handicapped by a lack of consensus on their mode of action. In this study, we identify three histones (H3.1, H2A, H2B) as possible targets for an anticancer redox organoruthenium compound (RDC11). Using purified histones, we confirmed an interaction between the ruthe...

Motivation „ Formal techniques not yet widely adopted by programmers. „ Commercial pressure to produce higher quality software is increasing. Motivation „ Formal techniques not yet widely adopted by programmers. „ Commercial pressure to produce higher quality software is increasing. „ Software developers favour so-called lightweight techniques that provide immediate returns and sit comfortably ...

BACKGROUND Several methods that are currently used for contouring analysis have problems providing reliable and/or meaningful results. In this paper a solution to these problems is proposed in a form of a novel measure, which was developed based on requirements defined for contouring studies. MATERIALS AND METHODS The proposed distance deviation measure can be understood as an extension of th...

The performance of nickel, ruthenium, and nickel-ruthenium impregnated on cerium oxide catalysts was tested in the methanation carbon dioxide reaction. nickel ruthenium contents were 4 0.4 wt%, respectively. properties studied using elementary analysis, Brunauer-Emmet-Teller specific surface area measurements, X-ray diffraction, temperature programmed reduction, desorption, H2 chemisorption tra...

The whole cell configuration of the patch-clamp technique was used to study the modulation gamma-aminobutyric acid (GABA)-mediated postsynaptic currents by ruthenium red in CA3 hippocampal neurons in slices obtained from postnatal (P) days P6-P10 old rats. In the presence of kynurenic acid (1 mM), ruthenium red (100 microM) completely blocked stimulus-elicited GABA-mediated postsynaptic current...