نتایج جستجو برای: run of homozygosity
تعداد نتایج: 21168121 فیلتر نتایج به سال:
OBJECTIVE There is an established association between the development of ankylosing spondylitis (AS) and the HLA-B27 allele, but whether or not homozygosity for HLA B27 has any additional effects on the clinical manifestations of AS is unclear. The aim of this study was to determine the influence of HLA-B27 homozygosity on the clinical manifestations of AS in Korea. METHODS A total of 490 pat...
Genome-wide patterns of homozygosity runs and their variation across individuals provide a valuable and often untapped resource for studying human genetic diversity and evolutionary history. Using genotype data at 577,489 autosomal SNPs, we employed a likelihood-based approach to identify runs of homozygosity (ROH) in 1,839 individuals representing 64 worldwide populations, classifying them by ...
P.40k INTRODUCTION. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 405 Homozygosity after eight generations. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 407 Homozygosity after fourteen generations. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...
To date very few studies have addressed the effects of inbreeding in social Hymenoptera, perhaps because the costs of inbreeding are generally considered marginal owing to male haploidy whereby recessive deleterious alleles are strongly exposed to selection in males. Here, we present one of the first studies on the effects of queen and worker homozygosity on colony performance. In a wild popula...
The objective of the present study was to assess the effects of genomic inbreeding on production, reproduction, and udder health in Holstein dairy cows. First and second lactation data were collected from 1,061 Holstein dairy cows, which were born between 2006 and 2008, from 5 commercial herds across the United States. All cows were genotyped for 54,609 single nucleotide polymorphism (SNP) mark...
Principal component analysis (PCA), homozygosity rate estimations, and linkage studies in humans are classically conducted through genome-wide single-nucleotide variant arrays (GWSA). We compared whole-exome sequencing (WES) and GWSA for this purpose. We analyzed 110 subjects originating from different regions of the world, including North Africa and the Middle East, which are poorly covered by...
a set of 18 simple sequence repeat (ssr) primer pairs was employed to assess the genetic diversity in a collection of 52 melon genotypes that consisted of 24 melon accessions representing different horticultural groups of iranian cultivated melons, along with 28 reference accessions from diverse foreign geographical origins. all the studied ssr loci were polymorphic, confirming their potential ...
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