نتایج جستجو برای: run of homozygosity

تعداد نتایج: 21168121  

Journal: :Clinical and experimental rheumatology 2009
T-J Kim K-S Na H-J Lee B Lee T-H Kim

OBJECTIVE There is an established association between the development of ankylosing spondylitis (AS) and the HLA-B27 allele, but whether or not homozygosity for HLA B27 has any additional effects on the clinical manifestations of AS is unclear. The aim of this study was to determine the influence of HLA-B27 homozygosity on the clinical manifestations of AS in Korea. METHODS A total of 490 pat...

Journal: :American journal of human genetics 2012
Trevor J Pemberton Devin Absher Marcus W Feldman Richard M Myers Noah A Rosenberg Jun Z Li

Genome-wide patterns of homozygosity runs and their variation across individuals provide a valuable and often untapped resource for studying human genetic diversity and evolutionary history. Using genotype data at 577,489 autosomal SNPs, we employed a likelihood-based approach to identify runs of homozygosity (ROH) in 1,839 individuals representing 64 worldwide populations, classifying them by ...

Journal: :Genetics 2003
D F Jones

P.40k INTRODUCTION. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 405 Homozygosity after eight generations. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 407 Homozygosity after fourteen generations. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...

Journal: :Journal of evolutionary biology 2009
C Haag-Liautard E Vitikainen L Keller L Sundström

To date very few studies have addressed the effects of inbreeding in social Hymenoptera, perhaps because the costs of inbreeding are generally considered marginal owing to male haploidy whereby recessive deleterious alleles are strongly exposed to selection in males. Here, we present one of the first studies on the effects of queen and worker homozygosity on colony performance. In a wild popula...

2012
D. W. Bjelland K. A. Weigel D. J. Nkrumah N. Vukasinovic G. R. Wiggans T. A. Cooper P. M. VanRaden

The objective of the present study was to assess the effects of genomic inbreeding on production, reproduction, and udder health in Holstein dairy cows. First and second lactation data were collected from 1,061 Holstein dairy cows, which were born between 2006 and 2008, from 5 commercial herds across the United States. All cows were genotyped for 54,609 single nucleotide polymorphism (SNP) mark...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2016
Aziz Belkadi Vincent Pedergnana Aurélie Cobat Yuval Itan Quentin B Vincent Avinash Abhyankar Lei Shang Jamila El Baghdadi Aziz Bousfiha Alexandre Alcais Bertrand Boisson Jean-Laurent Casanova Laurent Abel

Principal component analysis (PCA), homozygosity rate estimations, and linkage studies in humans are classically conducted through genome-wide single-nucleotide variant arrays (GWSA). We compared whole-exome sequencing (WES) and GWSA for this purpose. We analyzed 110 subjects originating from different regions of the world, including North Africa and the Middle East, which are poorly covered by...

Journal: :Hypertension 2021

Journal: :Nature 2007

Journal: :Offset 2017

Journal: :علوم باغبانی ایران 0
محمود رقامی پردیس کشاورزی و منابع طبیعی دانشگاه تهران محمد رضا حسندخت ذبیح اله زمانی پردیس کشاورزی و منابع طبیعی دانشگاه تهران محمد رضا فتاحی مقدم پردیس کشاورزی و منابع طبیعی دانشگاه تهران عبدالکریم کاشی پردیس کشاورزی و منابع طبیعی دانشگاه تهران آنا ایزابل لوپز سیز بخش بهنژادی گیاهی موسسه میوه های نیمه گرمسیری و مدیترانه ای لامایورا، مالاگا، اسپانیا

a set of 18 simple sequence repeat (ssr) primer pairs was employed to assess the genetic diversity in a collection of 52 melon genotypes that consisted of 24 melon accessions representing different horticultural groups of iranian cultivated melons, along with 28 reference accessions from diverse foreign geographical origins. all the studied ssr loci were polymorphic, confirming their potential ...

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