نتایج جستجو برای: rs9939609 polymorphism

تعداد نتایج: 107470  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2017
Kristina M Rapuano Amanda L Zieselman William M Kelley James D Sargent Todd F Heatherton Diane Gilbert-Diamond

Obesity is a major public health concern that involves an interaction between genetic susceptibility and exposure to environmental cues (e.g., food marketing); however, the mechanisms that link these factors and contribute to unhealthy eating are unclear. Using a well-known obesity risk polymorphism (FTO rs9939609) in a sample of 78 children (ages 9-12 y), we observed that children at risk for ...

2017
Ying Yang Boyang Liu Wei Xia Jing Yan Huan-Yu Liu Ling Hu Song-Mei Liu

Type 2 diabetes mellitus (T2DM) is a global health problem that results from the interaction of environmental factors with genetic variants. Although a number of studies have suggested that genetic polymorphisms in the fat mass and obesity-associated (FTO) gene are associated with T2DM risk, the results have been inconsistent. To investigate whether FTO polymorphisms associate with T2DM risk an...

2017
Margarita Rivera Adam E. Locke Tanguy Corre Darina Czamara Christiane Wolf Ana Ching-Lopez Yuri Milaneschi Stefan Kloiber Sara Cohen-Woods James Rucker Katherine J. Aitchison Sven Bergmann Dorret I. Boomsma Nick Craddock Michael Gill Florian Holsboer Jouke-Jan Hottenga Ania Korszun Zoltan Kutalik Susanne Lucae Wolfgang Maier Ole Mors Bertram Müller-Myhsok Michael J. Owen Brenda W. J. H. Penninx Martin Preisig John Rice Marcella Rietschel Federica Tozzi Rudolf Uher Peter Vollenweider Gerard Waeber Gonneke Willemsen Ian W. Craig Anne E. Farmer Cathryn M. Lewis Gerome Breen Peter McGuffin

BackgroundDepression and obesity are highly prevalent, and major impacts on public health frequently co-occur. Recently, we reported that having depression moderates the effect of the FTO gene, suggesting its implication in the association between depression and obesity.AimsTo confirm these findings by investigating the FTO polymorphism rs9939609 in new cohorts, and subsequently in a meta-analy...

2013
David Albuquerque Clévio Nóbrega Licínio Manco

BACKGROUND Several studies have reported an association between single nucleotide polymorphisms in the first intron of the FTO gene and body mass index (BMI) or obesity. However, this association has not yet been studied among the Portuguese population. This study aims to assess the association of three FTO polymorphisms (rs1861868, rs1421085 and rs9939609) with obesity-related outcomes in a sa...

2012
Fleur P. Velders Jolanda E. De Wit Pauline W. Jansen Vincent W. V. Jaddoe Albert Hofman Frank C. Verhulst Henning Tiemeier

The FTO minor allele at rs9939609 has been associated with body mass index (BMI: weight (kg)/height (m)(2)) in children from 5 years onwards, food intake, and eating behaviour. The high expression of FTO in the brain suggests that this gene may also be associated with behavioural phenotypes, such as impulsivity and control. We examined the effect of the FTO minor allele (A) at rs9939609 on eati...

2015
Huiqin Yuan Guoping Zhu Fang Wang Xiang Wang Huihui Guo Mo Shen

BACKGROUND Polycystic ovary syndrome (PCOS) is a common and complex endocrine-metabolic disease. One of the well-documented characteristics of PCOS is obesity or overweightness. It is possible to be genetically predisposed to becoming obese or overweight, and several potentially causative single nucleotide polymorphisms (SNPs), such as rs9939609 (A/T) in the fat mass, and obesity-associated gen...

2015
Asher Fawwad Iftikhar Ahmed Siddiqui Nimra Fatima Zeeshan Syed Muhammad Shahid Abdul Basit

OBJECTIVE To determine the association of SNP in FTO gene, rs9939609, with Metabolic Syndrome (MS) in type 2 diabetic subjects at a tertiary care unit of Karachi, Pakistan. METHODS We genotyped FTO rs9939609 SNP in 296 patients with type 2 diabetes from the Out Patient Department (OPD) of Baqai Institute of Diabetology and Endocrinology (BIDE). MS was defined on the basis of International Dia...

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