OBJECTIVE To determine long-term oncological outcomes of radical prostatectomy (RP) after neoadjuvant chemohormonal therapy (CHT) for clinically localised, high-risk prostate cancer. PATIENTS AND METHODS In this phase II multicentre trial of patients with high-risk prostate cancer (PSA level >20 ng/mL, Gleason ≥8, or clinical stage ≥T3), androgen-deprivation therapy (goserelin acetate depot) ...

BACKGROUND Renal pelvis dilatation (RPD) occurs in 1% of fetuses. Severe RPD (>15 mm) is frequently associated with urinary tract pathology. For the majority with mild (5 to 9 mm) to moderate (10 to 15 mm) RPD, however, there is uncertainty about the risk of abnormalities and how much postnatal investigation is required. STUDY DESIGN Systematic review of cohort studies of fetuses with RPD < o...

OBJECTIVES To evaluate the utility of preoperative multiparametric magnetic resonance imaging (MP-MRI) in predicting biochemical recurrence (BCR) following radical prostatectomy (RP). MATERIALS/METHODS From March 2007 to January 2015, 421 consecutive patients with prostate cancer (PCa) underwent preoperative MP-MRI and RP. BCR-free survival rates were estimated using the Kaplan-Meier method. ...

Urinary and sexual dysfunctions are side effects of radical prostatectomy (RP) for prostate cancer (PC) that contribute to depression. Despite the effectiveness of support groups at reducing depression in cancer patients, men typically do not participate in them. The purpose of this pilot study was to test the effects of a dyadic intervention (one-to-one support) on social support (Modified Inv...

introduction sectoral retinitis pigmentosa (rp) is a rare clinical condition. case presentation we present a 60-year-old female with a history of mild night blindness and decreased vision in the left eye for about 15 years. conclusions fundus examination revealed retinal pigmentary changes in the inferotemporal sector and reduced arterial caliber. in addition, fundus autofluorescence, fluoresce...

eperisone hydrochloride is a skeletal muscle relaxant and paracetamol is cyclooxygenase inhibitor. these drugs in combination are used as antispasmodics. a simple, specific, precise and accurate method was developed, namely reverse phase high performance liquid chromatography for simultaneous estimation of eperisone hydrochloride and paracetamol in tablet dosage form. in rp-hplc method separati...

Background: To investigate the expression of TNF-&alpha;, IL-6, IL-10 in the plasma of patients with lung cancer who received radiation therapy (RT), and to analyze the correlation between these cytokines and radiation pneumonitis (RP). Materials and Methods: Patients with lung cancer who received 3D-CRT in our hospital were prospectively evaluated. Circulating cytokine levels were measured wit...

A validated simple, sensitive, specific and precise RP-HPLC method was developed for the determination of Etravirine in pure and pharmaceutical formulations. Method was carried on Hypersil BDS C18 column (150 mm x 4.6 mm, 5 μ particle size) using phosphate buffer:acetontrile (35:65 v/v) as mobile phase. Detection was carried out by UV at 322 nm. The proposed method obeyed linearity in the range...

A validated simple, sensitive, specific and precise RP-HPLC method was developed for the determination of Rosuvastatin in pure and pharmaceutical formulations. Method was carried on Symmetry C18 column (100 X 4.6 mm i.d., particle size 3.5um,ACE) using acetontrile: phosphate buffer as mobile phase in the ratio of 60:40v/v/. The detection was carried out at 243nm using Waters (2659) UV-Visible d...