Cisplatin (CP) is one of the most active cytotoxic agents in the treatment of cancer and has adverse side effects such as hepatotoxicity and nephrotoxicity. The aim of this study was focused on investigating the possible protective effect of royal jelly (RJ) against oxidative stress caused by CP injury of the liver and inflammatory changes in male albino rats. Twenty four albino rats were divid...

Honeybee royal jelly is reported to have body-enlarging effects in holometabolous insects such as the honeybee, fly and silkmoth, but its effect in non-holometabolous insect species has not yet been examined. The present study confirmed the body-enlarging effect in silkmoths fed an artificial diet instead of mulberry leaves used in the previous literature. Administration of honeybee royal jelly...

Anna Gloria Sabatini, Gian Luigi Marcazzan, Maria Fiorenza Caboni, Stefan Bogdanov, Ligia Bicudo de Almeida-Muradian 4 1 CRAIstituto Nazionale di Apicoltura, Bologna, Italy. 2 Dipartimento di Scienze degli Alimenti, Università di Bologna, Italy. 3 Swiss Bee Research Centre Agroscope, Liebefeld Poseux, Berne, Switzerland. 4 Departamento de Alimentos e Nutrição Experimental, Faculdade de Ciências...

BACKGROUND Royal jelly is a nutritious substance produced by the young nurse bees and contains significant amounts of proteins which are important for cell growth and proliferation. The aim of this study was to evaluate the effect of royal jelly as an alternative to fetal bovine serum (FBS) in cell culture using cell proliferation assays and live cell imaging. MATERIALS AND METHODS MRC-5 cell...

Objectives: Royal jelly (RJ), a secretion of both the hypopharyngeal and mandibular glands of nurse workers, is believed to play a central role in honeybee queen development. Important component of royal jelly are proteins which form about 50% of the dry mass of RJ. Major royal jelly proteins (MRJPs) are the dominant proteinaceous component of royal jelly and constitute about 82-90% of total pr...

Background: Phenylhydrazine (PHZ) is used to induce experimental anemia in animal models. On the other hand royal jelly is known as antioxidant compound. Therefore, here in present study we aimed to evaluate the protective effect of royal jelly on PHZ-induced damages in testicular tissue and compare its impact with vitamin C. Materials and Methods: Eighteen mature male mice were randomly divide...

UNLABELLED Objectives : The aim of the present study was to evaluate protective effect of royal jelly on sperm parameters, testosterone level, and malondialdehyde (MDA) production in mice. MATERIALS AND METHODS Thirty-two adult male NMRI mice weighing 30±2 g were used. All the animals were divided into 4 groups. CONTROL GROUP received saline 0.1 ml/mouse/day orally for 30 days. Royal jelly ...

Honeybee colonies (Apis mellifera) serve as attractive hosts for a variety of pathogens providing optimal temperatures, humidity, and an abundance of food. Thus, honeybees have to deal with pathogens throughout their lives and, even as larvae they are affected by severe brood diseases like the European Foulbrood caused by Melissococcus plutonius. Accordingly, it is highly adaptive that larval f...

In the eusocial honey bee Apis mellifera, with reproductive queens and sterile workers, a female larva's developmental fate depends on its diet; nurse bees feed queen-destined larvae exclusively royal jelly, a glandular secretion, but worker-destined larvae receive royal jelly for 3 days and subsequently jelly to which honey and beebread are added. RNA-Seq analysis demonstrated that p-coumaric ...