BACKGROUND Palmitoylethanolamide (PEA) is a cannabimimetic compound that has been investigated as an analgesic agent in animal models and clinical trials. OBJECTIVES We conducted a meta-analysis to examine the efficacy of PEA for treating pain in randomized, controlled trials. STUDY DESIGN Systematic review and meta-analysis. SETTING This meta-analysis examined all randomized, controlled ...

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Three experiments were conducted to determine the effect of increasing field pea level in high-concentrate finishing cattle diets on ADG, DMI, G:F, and carcass traits, and to estimate the NE of field pea. In Exp. 1, 118 yearling heifers (417.9 +/- 2.4 kg initial BW) were blocked by initial BW and assigned randomly to 1 of 4 treatments (0, 10, 20, or 30% dry-rolled field pea, DM basis; 4 pens/tr...

Poly(1,4-butylene adipate) (PBA) and poly(ethylene adipate) (PEA), each with the ability to form ring-banded morphologies at same Tc, were simultaneously crystallized from mixtures of various compositions. Investigations on morphology, phase and thermal behavior were conducted in order to reveal lamellar packing and spherulitic structures in this binary system. As PBA is faster-crystallizing an...

Beta-phenylethylamine (PEA) induced an increase in cytosolic free calcium ion concentration ([Ca2+]c) in Saccharomyces cerevisiae cells monitored with transgenic aequorin, a Ca2+-dependent photoprotein. The PEA-induced [Ca2+]c increase was dependent on the concentrations of PEA applied, and the Ca2+ mostly originated from an extracellular source. Preceding the Ca2+ influx, H2O2 was generated in...

BACKGROUND Pea protein (from Pisum sativum) is under consideration as a sustainable, satiety-inducing food ingredient. OBJECTIVE In the current study, pea-protein-induced physiological signals relevant to satiety were characterized in vitro via gastric digestion kinetics and in vivo by monitoring post-meal gastrointestinal hormonal responses in rats. DESIGN Under in vitro simulated gastric ...

Legumes are important crop plants and pea (Pisum sativum L.) has been investigated as a model with respect to several physiological aspects. The sequencing of the pea genome has not been completed. Therefore, proteomic approaches are currently limited. Nevertheless, the increasing numbers of available EST-databases as well as the high homology of the pea and medicago genome (Medicago truncatula...

ERRAH and KONETZKA (1962) reported that phenethyl alcohol (PEA) selectively and reversibly inhibits DNA synthesis in Escherichia coli. It was subsequently shown that PEA inhibits the initiation of a new cycle of DNA replication in this organism but permits the completion of those cycles initiated before addition of PEA to the medium (TREICK and KONETZKA 1964). We reasoned therefore that genetic...

for treatment of anti-nutritional factors(anfs), (?-n-oxalyl -l- ?, ? -diaminopropionic acid (?-odap) and condensed tannin (ct)) in grass pea, some such alkali treatments as naoh, nahco3, kmno4 and wood ash, besides water soaking and polyethylene glycol (peg) (6000 mw) were employed . metabolizable energy (me) of treated and of untreated grass pea was assessed using gas production technique, tw...

Activation of Raf-1 suppresses integrin activation, potentially through the activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2). However, bulk ERK1/2 activation does not correlate with suppression. PEA-15 reverses suppression of integrin activation and binds ERK1/2. Here we report that PEA-15 reversal of integrin suppression depends on its capacity to bind ERK1/2, indicating t...