In a healthy body, reactive oxygen species (ROS) and antioxidants remain in balance. Oxidative stress occurs when the generation of reactive oxygen species and other radical species exceeds the scavenging capacity by antioxidants of antioxidative agents in organism, due to excessive production of reactive oxidagen species and/or inadequate intake or increased utilization of antioxidants. Most R...

Reactive oxygen species (ROS) are essential intermediates in oxidative metabolism. Nonetheless, when generated in excess, ROS can damage cells by peroxidizing lipids and disrupting structural proteins, enzymes and nucleic acids. Excess ROS are generated during a variety of cell stresses, including ischemia/reperfusion, exposure to ionizing and ultraviolet radiation and/or infl ammation. Reactiv...

background & aim: glycyrrhiza l. (fabaceae) consists of perennial herbs grow in sandy soils with hard lightness. three species of the genus grow in iran, among them g. glabra l. has the widest distribution. it is well known in english as licorice and the root extract includes flavonoids and glycyrrhizin are used widely in medicine, food industry, tobacco products and other industries. liqui...

Background: This study was carried out to evaluate the pattern of reactive oxygen species (ROS) variations during in vitro oocyte maturation and embryo development in sheep, and to investigate whether embryo culture condition and the presence of cell-permeable superoxide dismutase mimetic [Manganese (III) meso-tetrakis (4-benzoic acid) porphyrin (MnTBAP)] can influence ROS pattern. Materials an...

In vitro maturation (IVM) is emerging as a popular technology at the forefront of fertility treatment and preservation. However, standard in vitro culture conditions usually increase reactive oxygen species (ROS), which have been implicated as one of the major causes for reduced embryonic developmental competence. It is well-known that higher than physiological levels of ROS triggers granulosa ...

Reactive oxygen species (ROS) are by-products of normal aerobic cellular metabolism, which relatively reactive, partially reduced, and play important physiological roles in maintaining homeostasis.

collection of multiple processes that increase the chronological age of an organism leading to death is defined as aging, and even though important, it is poorly understood. recent research has shown that aging is due to biochemical and genetic changes, in interaction with environmental effects, including diet and nutrition. most knowledge on aging is based on ge­netic model system, but its mol...

infertility is one of the most stressful conditions amongst married couples. male factor infertility is implicated in almost half of these cases. recent advances in the field of reproductive medicine have focused the attention of many researchers to consider reactive oxygen species (ros) as one of the mediators of infertility causing sperm dysfunction. although, ros is involved in many physiolo...

metals can cause oxidative stress by increasing the formation of reactive oxygen species (ros), which make antioxidants incapable of defiance against growing amounts of free radicals. metal toxicity is related to their oxidative state and reactivity with other compounds. however, several reports about metals have been published in the recent years. mitochondria, as a site of cellular oxygen con...

The generation of reactive oxygen radicals in mammalian cells profoundly affects numerous critical cellular functions, and the absence of efficient cellular detoxification mechanisms which remove these radicals can result in several human diseases. Growing evidence suggests that reactive oxygen species (ROS) within cells act as second messengers in intracellular signaling cascades which induce ...