نتایج جستجو برای: ror1

تعداد نتایج: 253  

2017
CE Henry C Emmanuel N Lambie C Loo B Kan CJ Kennedy A de Fazio NF Hacker CE Ford

OBJECTIVE The ROR1 and ROR2 receptor tyrosine kinases have both been implicated in ovarian cancer progression and have been shown to drive migration and invasion. There is an increasing importance of the role of stroma in ovarian cancer metastasis; however, neither ROR1 nor ROR2 expression in tumor or stromal cells has been analyzed in the same clinical cohort. AIM To determine ROR1 and ROR2 ...

Journal: :avicenna journal of medical biotechnology 0

it has recently been shown that ror1, a member of the receptor tyrosine kinase family, is overexpressed in leukemic b cells of chronic lymphocytic leukemia (cll) and a subset of acute lymphoblastic leukemia (all). in this comparative study the expression profile of ror1 mrna was investigated in iranian patients with cll and acute myelogenous leukemia (aml) and the results were compared with tho...

2017
Guangzhen Hu Shiv K. Gupta Tammy P. Troska Asha Nair Mamta Gupta

Mantle cell lymphoma (MCL) is an aggressive B-cell lymphoma characterized by rapid disease progression. The needs for new therapeutic strategies for MCL patients call for further understanding on the molecular mechanisms of pathogenesis of MCL. Recently, long noncoding RNAs (lncRNAs) have been recognized as key regulators of gene expression and disease development, however, the role of lncRNAs ...

Journal: :Antibody reports 2022

The recombinant antibodies RB702, RB703, RB704 and RB705 detect by ELISA a synthetic peptide from the ROR1 protein.

2011
Jiahui Yang Sivasubramanian Baskar Ka Yin Kwong Michael G. Kennedy Adrian Wiestner Christoph Rader

BACKGROUND Based on its selective cell surface expression in chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL), receptor tyrosine kinase ROR1 has recently emerged as a promising target for therapeutic monoclonal antibodies (mAbs). To further assess the suitability of ROR1 for targeted therapy of CLL and MCL, a panel of mAbs was generated and its therapeutic utility was investiga...

2016
Tomoya Yamaguchi Can Lu Lisa Ida Kiyoshi Yanagisawa Jiro Usukura Jinglei Cheng Naoe Hotta Yukako Shimada Hisanori Isomura Motoshi Suzuki Toyoshi Fujimoto Takashi Takahashi

The receptor tyrosine kinase-like orphan receptor 1 (ROR1) sustains prosurvival signalling directly downstream of the lineage-survival oncogene NKX2-1/TTF-1 in lung adenocarcinoma. Here we report an unanticipated function of this receptor tyrosine kinase (RTK) as a scaffold of cavin-1 and caveolin-1 (CAV1), two essential structural components of caveolae. This kinase-independent function of ROR...

Journal: :Mechanisms of Development 2001
Takeru Matsuda Masashi Nomi Makoto Ikeya Shuichi Kani Isao Oishi Toshio Terashima Shinji Takada Yasuhiro Minami

In mammals, the Ror-family receptor tyrosine kinases consist of two structurally related proteins, Ror1 and Ror2, characterized by the extracellular Frizzled-like cysteine-rich domain and membrane proximal kringle domains. As an attempt to gain insights into their roles in mouse development, expression patterns of Ror1 and Ror2 during early embryogenesis were examined and compared. Interestingl...

Journal: :Journal of molecular recognition : JMR 2013
Mi Li Xiubin Xiao Lianqing Liu Ning Xi Yuechao Wang Zaili Dong Weijing Zhang

Knowledge of drug-target interaction is critical to our understanding of drug action and can help design better drugs. Due to the lack of adequate single-molecule techniques, the information of individual interactions between ligand-receptors is scarce until the advent of atomic force microscopy (AFM) that can be used to directly measure the individual ligand-receptor forces under near-physiolo...

2013
Michael Hudecek Maria-Teresa Lupo-Stanghellini Paula L. Kosasih Daniel Sommermeyer Michael C. Jensen Christoph Rader Stanley R. Riddell

Purpose: The adoptive transfer of T cells modified to express a chimeric antigen receptor (CAR) comprised of an extracellular single-chain antibody (scFV) fragment specific for a tumor cell surface molecule, and linked to an intracellular signaling module, has activity in advanced malignancies. The receptor tyrosine kinase–like orphan receptor 1 (ROR1) is a tumor-associated molecule expressed i...

2014
S Carolina Berger Daniel Sommermeyer Michael Hudecek Michael Berger Ashwini Balakrishnan Paulina Paskiewicz Paula Kosasih Christoph Rader Stanley Riddell

Background Immunotherapy with T cells expressing chimeric antigen receptors (CARs) specific for a tumor cell-surface molecule is effective for CD19 B cell malignancies. There is interest in extending CAR-T cell therapy to epithelial tumors, which requires identifying molecules that can be targeted safely. The receptor tyrosine kinase-like orphan receptor 1 (ROR1) is expressed at the cell-surfac...

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