ROCK inhibition has been largely applied as a strategy to treat neurodegenerative diseases (NDDs) and promising results have been obtained in the recent years. However, the underlying molecular and cellular mechanisms are not fully understood and different models have been proposed for neurodegenerative disorders. Here, we aim to review the current knowledge obtained for NDDs identifying common...

The role of the RhoA/Rho kinase (ROCK) signaling pathway in cell survival remains a very controversial issue, with its activation being pro-apoptotic in many cell types and anti-apoptotic in others. To test if ROCK inhibition contributes to tumor cell survival or death following chemotherapy, we treated cisplatin damaged neuroblastoma cells with a pharmacological ROCK inhibitor (Y27632) or sham...

Rock bolts have been widely used as rock reinforcing members in underground coal mine roadways and tunnels. Failures of rock bolts occur as a result of overloading, corrosion, seismic burst and bad grouting, leading to catastrophic economic and personnel losses. Monitoring the health condition of the rock bolts plays an important role in ensuring the safe operation of underground mines. This wo...

Since rock fracture is a key property for different rock engineering applications, rock fracture measurement is often carried out in classifying the rock mass. Most geo-mechanics models (e.g. finite element) are of the equivalent continuum type in which fractures are represented not individually, but by their influence on a large element of the rock mass. Elastic modulus, for example, is obtain...

the main purpose of this investigation is to study the effect of near miscible co2 injection in different porous mediums on both lab and field scales. this effect can be traced by the change of two-phase gas-oil relative permeability curves. in this work, the experiments have been performed on three rock types (i.e. sandstone, dolomite, and artificial fractured sandstone) based on an incrementa...

protein serine/threonine kinase (ROCK), is one of the central regulatory molecules for cytoskeleton control and cell adhesion process. ROCK also involves in other cell functions such as apoptosis and tumor invasiveness. Rho kinase is thought to play an important role in a variety of cellar functions such as stress fiber formation, focal adhesion formation, cell aggregation, cell morphology, cyt...

Determination of porosity, permeability, and pore volume compressibility of reservoir rocks and those variations with effective stress changes are of great interest in petroleum engineering. This paper has studied the influence of pore types of carbonate reservoir rocks on pore volume compressibility as well as Klinkenberg permeability and porosity at different stress values. In the current stu...

Texture analysis and classification are usual tasks in pattern recognition. Rock texture is a demanding classification task, because the texture is often non-homogenous. In this paper, we introduce a rock texture classification method, which is based on textural and spectral features of the rock. The spectral features are considered as some color parameters whereas the textural features are cal...