OBJECTIVES To investigate the occurrence of 16S rRNA methylases conferring high-level resistance to aminoglycosides in Enterobacteriaceae isolated from two pig farms in China. METHODS Enterobacteriaceae isolated from 151 pig rectal swab samples and 9 environmental samples were screened for the presence of the rmtA, rmtB, armA and rmtC genes by PCR and sequencing. Conjugation experiments were ...

introduction: this in vitro study compared the cytotoxic effects of three commercially available mta formulations naming proroot mta (pmta), angelus mta (amta), and root mta (rmta), with calcium-enriched mixture (cem) cement and a new nanohybrid mta (nmta) on human dental pulp stem cells (dpsc). methods and materials: four disc-shaped specimens of each material were prepared. after completion o...

Dear Sir, Enterobacteriaceae, other than Escherichia spp. and Klebsiella spp., can cause serious nosocomial infections and appear to have become increasingly drug resistant. Citrobacter freundii, belonging to the Enterobacteriaceae family, is a prominent opportunistic pathogen responsible for serious infections in immunocompromised individuals. C. freundii is characterized by the presence of ch...

Background & objective: Multidrug-resistant Acinetobacter baumannii (MDR-AB) is an important nosocomial pathogen which is associated with significant morbidity and mortality, particularly in high-risk populations. Aminoglycoside-modifying enzymes (AMEs) and 16S ribosomal RNA (16S rRNA) methylation are two important mechanisms of resistance to ...

Over the last decade, nosocomial infections with Acinetobacter baumannii have been described with an increasing trend toward multidrug resistance, mostly in intensive care units (ICUs) (6, 9, 11). The main mechanism of resistance to carbapenems in A. baumannii is the production of acquired OXA-type carbapenemases, which have been frequently identified worldwide and are clustered in three major ...

To the Editor: Carbapenemase-producing Enterobacteriaceae are being reported worldwide. Travel, medical tourism, and cross-border transfer of patients might play a role in the spread of these bacteria (1,2). Klebsiella pneumoniae co-producing New Delhi metallo-β-lactamase 5 (NDM-5) and oxacillinase 181 (OXA-181) carbapenemases was detected in South Korea in 2014. On April 13, a 75-year-old man ...

Proteus mirabilis isolate JIE273 was recovered in March 2007 from the urine of an inpatient at Blacktown Hospital, Sydney. In vitro susceptibility tests (Phoenix NMIC/ID-101 panel; BD, Franklin Lakes, NJ) indicated that JIE273 was susceptible to imipenem (MIC, 2 g/ml), cefoxitin (MIC, 4 g/ml), amoxicillin-clavulanate (MIC, 4/2 g/ml), and ticarcillin-clavulanate (MIC, 2/2 g/ml). It had “intermed...

Dr. Marilyn C. Roberts and Dr. Stefan Schwarz have contacted the authors of the original publication with several comments and suggestions to better harmonize the correct nomenclature of the antibiotic resistance genes, as the gene names were not always correctly presented in the various tables given. Authors often pick their own gene names which in many cases have been approved for use for oth...