Onchocerciasis, or river blindness, is a neglected tropical disease caused by the filarial nematode Onchocerca volvulus that affects more than 37 million people, mainly in third world countries. Currently, the only approved drug available for mass treatment is ivermectin, however, drug resistance is beginning to emerge, thus, new therapeutic targets and agents are desperately needed to treat an...

Efforts to control Onchocerca volvulus, the etiologic agent of river blindness, have been limited to vector control and drug treatment to eliminate microfilariae, with no means available to prevent infection. The goal of this study was to develop a vaccine against this infection using recombinant antigens that are expressed in the early larval stages of the parasite. Five recombinant antigens, ...

British Journal of DermatologyVolume 184, Issue 2 p. e39-e39 Plain Language SummaryFree Access Measuring the impact skin disease caused by onchocerciasis (river blindness) First published: 05 February 2021 https://doi.org/10.1111/bjd.19730AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text full-text accessPlease review our Terms an...

Onchocerciasis (also known as ‘river blindness’), is a neglected tropical disease (NTD) caused by the (Simulium-transmitted) filarial nematode Onchocerca volvulus. The occurrence of ‘blinding’ (savannah) and non-blinding (forest) parasite strains existence corresponding, locally adapted Onchocerca–Simulium complexes were postulated to explain greater blindness prevalence in savannah than forest...

Human filarial nematodes cause river blindness and lymphatic filariasis, both of which are diseases that produce considerable morbidity. Control of these diseases relies on drug treatments that are ineffective against macrofilariae and are threatened by the development of resistance. New validated drug targets are required to allow development of new classes of antifilarial drugs. To identify a...