The aim of this work was to evaluate the effects of BM-567 (N-pentyl-N'-[(2-cyclohexylamino-5-nitrobenzene)sulfonyl]urea), a torasemide derivative, on both thromboxane A(2) (TXA(2)) receptors (TP) and thromboxane synthase of human platelets. The drug affinity for TP receptors of human washed platelets has been determined. In this test, BM-567 showed a high affinity (IC(50): 1.1+/-0.1nM) for the...

The development of rills on a hillslope whose soil is amended by biochar remains topic to be developed. A theoretical rill flow resistance equation, obtained the integration power velocity distribution, was assessed using available measurements at plot scale with added soil. incorporated and mixed arable content BC 6 12 kg m−2. developed analysis demonstrated that an accurate estimate profile p...

This issue of Sleep Science contains two excellent review articles by Garcia-Rill and his colleagues examining the role of reticular activating system, especially the pedunculopontine (PPT) nucleus, in the pathophysiology of insomnia, schizophrenia, and other neuropsychiatric disorders [1,2]. The PPT nucleus is one of the major aggregations of cholinergic neurons in the mammalian brainstem capa...

Modulation of gamma oscillations in the pedunculopontine nucleus (PPN) by 1 neuronal calcium sensor protein-1 (NCS-1): 2 Relevance to schizophrenia and bipolar disorder 3 4 Stasia D’Onofrio, Nebojsa Kezunovic, James R. Hyde, Brennon Luster, 5 Erick Messias, Francisco J. Urbano, and Edgar Garcia-Rill 6 Center for Translational Neuroscience, 7 Departments of Neurobiology and Developmental Science...

When comparing the average citation impact of research groups, universities and countries, field normalisation reduces the influence of discipline and time. Confidence intervals for these indicators can help with attempts to infer whether differences between sets of publications are due to chance factors. Although both bootstrapping and formulae have been proposed for these, their accuracy is u...

In its dormant state, the membrane cytoskeletal linker protein ezrin takes on a NH(2) terminal-to-COOH terminal (N-C) binding conformation. In vitro evidence suggests that eliminating the N-C binding conformation by Thr(567) phosphorylation leads to ezrin activation. Here, we found for resting gastric parietal cells that the levels of ezrin phosphorylation on Thr(567) are low and can be increas...

Unheard Voices A. G. Graham, F.R.C.S.ED.; C. G. Elliott, B.M . .................................................. 563 Hypocalcaemia and Breast-feeding D. J. Pearce, M.B............................... 563 Ergometrine D. D. Moir, F.F.A.R.C.S......................... 563 Errant Genes R. Duguid, M.SC . ................ 563 Recurrent Virus Meningitis E. Klemola, M.D.....................................

II. THE ORIGIN OF LAW......................................564 A. LAW AS OBLIGATION......................................565 B. LAW AS INDIVIDUAL CLAIM............................................................567 1. The Minimum Common Meaning of the Word “Law”................................................567 2. The Concept of Claim...........................568 3. The Theory of Law as Excha...