The relationship of riboflavin to cancer is intriguing but many gaps remain in our knowledge. Several studies indicate that riboflavin deficiency inhibits tumor growth in experimental animals and possibly in man, but the precise mechanisms involved have not been elucidated. Azo dye carcinogenesis in liver appears to be a special case in that riboflavin deficiency increases the potency of these ...

Several reports in the literature suggest a possible relationship between riboflavin deficiency and anemia. Intramuscular administration of purified flavin prepared from liver was reported by Stare and Thompson (1) to have no effect on hemoglobin, erythrocyte, or reticulocyte response in patients with pernicious anemia. However, Miller and Rhoads (2) were able to produce in dogs a syndrome simi...

BACKGROUND: Brown-Vialetto-Van Laere syndrome (BVVLS) is a rare, treatable neurodegenerative disorder with variable clinical presentation, caused by mutations in three different riboflavin transporter genes. CASE: An 11-year-old-boy presented respiratory insufficiency and rapidly progressive muscle weakness. He was the fifth child of consanguineous marriage medical history hearing loss. peri...

RIBOFLAVIN OR VITAMIN B2 (7,8-dimethyl-10-ribitylisoalloxazine) is an essential water-soluble vitamin. Riboflavin is important for normal cell functioning and for cell growth and development. Riboflavin is a major component of coenzymes FAD and flavin mononuclotide (FMN) that play a key role in the metabolism of carbohydrates, amino acids, and lipids. Riboflavin is also intimately involved in t...

Riboflavin deficiency can cause a variety of metabolic problems that lead to skin and mucosal disorders. Limited evidence suggests that high intake of riboflavin may reduce overall risks of cancer. However, association of this deficiency with cervical cancer and precancerous lesions are still not definitively known. In this study, we characterized the relationship between plasma and tissue ribo...

Riboflavin deficiency in weanling rats causes a metabolic disorder characterized by failure to oxidize fatty acids. The disorder is similar to that seen in several human diseases, some of which are responsive to pharmacological doses of riboflavin. Previous analysis of the riboflavin-deficient rat has shown that the failure of fatty acid oxidation is due to a decrease in the activity of the acy...

The successful treatment by riboflavin of a number of cases of superficial keratitis was described in two previous papers (Aykroyd and Verma, 1942; Verma, 1942). In the course of this work it was observed that a number of patients with superficial keratitis, associated with angular stomatitis and other signs of riboflavin deficiency, were also suffering from angular conjunctivitis, and that the...