Frank Eliassen, Anders Andersen, Gordon S. Blair, Fabio Costa, Geoff Coulson, Vera Goebel, Øivind Hansen, Tom Kristensen, Thomas Plagemann, Hans Ole Rafaelsen, Katia B. Saikoski, Weihai Yu 'HSDUWPHQW RI ,QIRUPDWLFV 8QLYHUVLW\ RI 2VOR 1RUZD\ Á'LVWULEXWHG 0XOWLPHGLD 5HVHDUFK *URXS &RPSXWLQJ 'HSDUWPHQW /DQFDVWHU 8QLYHUVLW\ 8. ‚'HSDUWPHQW RI &RPSXWHU 6FLHQFH 8QLYHUVLW\ RI 7URPV¡ 1RUZD\ )DFXOW\ RI (...

$EVWUDFW 7KH JRDO RI WKLV ZRUN LV WR SUHVHQW DQ H[SHULHQFH LQ WKH FKDOOHQJH RI XVLQJ ,QWHUQHW WHFKQRORJLHV IRU WKH GHYHORSPHQW RI D PXOWLPHGLD ZHE EDVHG PHGLFDO DSSOLFDWLRQ XVLQJ ERWK PXOWLPHGLD FRPSXWLQJ WHFKQRORJLHV DQG REMHFW RULHQWHG WHFKQRORJLHV 7KLV PHGLFDO DSSOLFDWLRQ LV IRFXVHG RQ WKH GHYHORSPHQW GLIIXVLRQ DQG XVH RI WKH WHFKQRORJ\ LQ UHVSRQVH WR VSHFLILF GRPDLQ QHHGV RI PHGLFDO H[SHUWV...

OBJECTIVE Whether patients with renal insufficiency (RI) undergoing percutaneous coronary interventions (PCI) benefit from abciximab added to clopidogrel plus aspirin is unknown. METHODS The study included 2,159 patients with coronary artery disease undergoing elective PCI. RI was assessed using glomerular filtration rate (GFR) cutoff values: moderate-to-severe RI (GFR <or=60 ml/min), mild RI...

Web Appendix A: Derivation of P (∆i = δi, Ri = j|Xi) Clearly the pair of random variables (∆i, Ri), or equivalently (∆i,Ri+1, Ri), is completely determined by (Ti, Ci). In particular, the set {∆i,Ri+1 = 0, Ri = j} is equivalent to observing the event in (tj−1, tj], which in turn is equivalent to the set {Ti ∈ (tj−1, tj], Ci ≥ tj}; and the set {∆i,Ri+1 = 1, Ri = j} is equivalent to censoring the...

,PDJH SURFHVVLQJ PRVW IUHTXHQWO\ XVHV WKH WUDQVIRUPV OLNH 'LVFUHWH &RVLQH 7UDQVIRUP RU )RXULHU WUDQVIRUP IRU LPDJH FRPSUHVVLRQ 7KLV LQYROYHV WKH FRQYHUVLRQ RI WKH VRXUFH VLJQDO WR IUHTXHQF\ FRPSRQHQW 7KH DSSOLFDWLRQ RI )UDFWLRQDO YHUVLRQ RI FRVLQH WUDQVIRUP FDOOHG 'LVFUHWH )UDFWLRQDO &RVLQH 7UDQVIRUP WR LPDJH FRPSUHVVLRQ LV IDLUO\ QHZ ')5&7 VKDUHV PDQ\ XVHIXO SURSHUWLHV RI UHJXODU '&7 LW KDV IU...

We assessed efficacy, safety, and reversal of renal impairment (RI) in untreated patients with multiple myeloma given bortezomib-melphalan-prednisone-thalidomide followed by bortezomib-thalidomide (VMPT-VT) maintenance or bortezomib-melphalan-prednisone (VMP). Exclusion criteria included serum creatinine ≥ 2.5 mg/dL. In the VMPT-VT/VMP arms, severe RI (estimated glomerular filtration rate [eGFR...

PURPOSE: Refractive index (RI) is unique in discriminating various tissues. It is dependent on water and solid components such as protein and phospholipid of brain tissue resembling hydrogel. Our purpose was to determine RI of normal and pathological tissues of brain from the MR T2 relaxation time (T2 value) to determine relative water and solid contents of a tissue and discriminate various pat...

OBJECTIVE To evaluate the pharmacokinetics of prucalopride in individuals with renal impairment (RI). METHODS This open-label Phase I study (ClinicalTrials.gov identifier: NCT01674192) enrolled men and women aged 18-75 years who were classified by renal function: normal renal function (creatinine clearance ≥ 80 mL/min/1.73 m²), mild RI (50-79 mL/min/1.73 m²), moderate RI (25-49 mL/min/1.73 m²...

background: in this study, we aimed to investigate the ability of transvaginal doppler ultrasonography in predicting in vitro fertilization (ivf) outcome in women undergoing this procedure. materials and methods: in this prospective observational study, 65 infertile women underwent ivf procedure in isfahan, during 2013-2014, were studied. the pulsatility index (pi), resistive index (ri) and pea...

OBJECTIVES Radioiodine (RI) therapy is known to subject cellular components of salivary glands (SG) to oxidative stress leading to SG dysfunction. However, the protective effects of antioxidants on RI-induced SG damage have not been well investigated. The authors investigated the morphometric and functional effects of epigallocatechin-3-gallate (EGCG) administered prior to RI therapy and compar...