BACKGROUND Early diagnosis of rheumatoid arthritis allows prompt initiation of antirheumatic therapy, which is associated with improved outcome. The use of IgM rheumatoid factor, the most widely used serologic test in assisting the diagnosis of rheumatoid arthritis, is limited by low specificity. An enzyme-linked immunosorbent assay test detecting antibodies to cyclic citrullinated peptide (CCP...

Rheumatoid factor became the first laboratory marker of rheumatoid arthritis and one serological markers used to recognize major autoimmune diseases. Details discovery with special regard contribution E. Waaler H. Rose are presented in this historical review. Same assays exam factor, its frequency modern view on diagnostic significance different diseases described article.

OBJECTIVE To determine the diagnostic and prognostic test qualities of the enzyme linked immunosorbent assays (ELISA) for rheumatoid factor isotypes in rheumatoid arthritis (RA), and to compare them with the latex fixation test. METHODS Rheumatoid factor tests were performed in 1988 consecutive new rheumatology outpatients within two months after their first visit to the outpatient clinic of ...

Cardiac necrobiotic lesions resembling rheumatoid granulomas were discovered in 2 patients without evidence of arthritis. Evidence from the literature indicates that pulmonary and subcutaneous nodules may occur before arthritis or before the appearance of the rheumatoid factor, and that cardiac lesions may occur early in the course of rheumatoid disease. Even in the absence of obvious arthritis...

A solid-phase radioimmunoassay was developed to detect immunoglobulin (Ig)E antibodies that bound to human IgG. IgE-rheumatoid factor activity was found in the serum of 18 of 20 patients with seropositive rheumatoid arthritis, 1 of 4 patients with seronegative rheumatoid arthritis, 3 of 32 patients with seronegative rheumatoid arthritis, 3 of 32 patients with asthma, and in 1 patient with hypoc...

Methotrexate nodulosis in conditions other than rheumatoid arthritis is very rare. It has been reported in a patient with systemic lupus erythematosus and Jaccoud’s arthropathy [4], a patient with juvenile arthritis who was rheumatoid factor negative [5], and a patient with psoriatic arthritis and negative rheumatoid factor [6]. Only the patient with juvenile arthritis had pulmonary nodules. Ho...

The rheumatoid factor, a group of unusual macroglobulins, is demonstrable in the serum of the majori ty of patients with rheumatoid arthritis and in a relatively small proportion of patients with other diseases (1). The presence of this factor can be demonstrated by its reaction with human v-globulin (Cohn fraction I I ) in such serological procedures as the tanned sheep cell agglutination (2) ...

The clinical features of a group of 79 patients with older age onset rheumatoid arthritis (ORA) were compared with those of a group of 414 patients with younger age onset rheumatoid arthritis. The ORA group contained approximately equal numbers of men and women, were less rheumatoid factor positive, had a raised erythrocyte sedimentation rate, lower HLA-DR4 positivity, and a tendency towards la...

762 IntroductIon Rheumatoid arthritis (RA) is a chronic crippling disease that causes significant morbidity and even mortality. The etiology is not known and hence the diagnosis is based on the typical clinical picture of inflammatory symmetrical polyarthritis supported by imaging and serological investigations. Among the serological investigations, rheumatoid factor (RF) is the most widely use...