The D antigen of the Rhesus blood group, an erythroid-specific cell surface marker, is expressed by all morphologically recognizable human nucleated red blood cell precursors including, in low density, the pronormoblast. The object of the present study was to determine the expression of the D antigen by committed erythroid progenitors. Under conditions that produced complete inhibition of BFU-E...

Rhesus (Rh) proteins were first identified in human erythroid cells and recently in other tissues. Like ammonia transporter (Amt) proteins, their only homologues, Rh proteins have the 12 transmembrane-spanning segments characteristic of transporters. Many think Rh and Amt proteins transport the same substrate, NH(3)/NH(4)(+), whereas others think that Rh proteins transport CO(2) and Amt protein...

Recently human interleukin-3 (IL-3) produced by molecular cloning was characterized as a growth factor for basophils and eosinophils in human bone marrow cultures. Since we found a similar activity of the human factor on simian bone marrow cells, we investigated the in vivo effects of recombinant human (rh) IL-3 in healthy rhesus monkeys (n = 10). rh IL-3 was administered subcutaneously (SC) to...

Since the introduction of anti-Rhesus (Rh) D prophylaxis for RhD-negative women, other Rh and non-Rh red cell alloantibodies have become relatively more important and are now responsible for the greater proportion of haemolytic disease of the newborn. Anti-C and anti-E are the most commonly implicated non-D Rh antibodies in the pathogenesis of haemolytic disease of the newborn'. In 1977 Peppere...

Rabbit polyclonal antibodies were raised against synthetic peptides corresponding to hydrophilic regions of the human Rhesus (Rh) IX cDNA-encoded polypeptide predicted to be extracellularly or intracellularly exposed in the topologic model of the Rh blood group protein. Four antibodies encompassing residues 33-45 (MPC1 ), 224-233 (MPC4), 390-404 (MPC6), and 408-41 6 (MPC8) were characterized an...

Blood group system was discovered way back in 1901 by Karl Landsteiner, Clinically, only ‘ABO’ and ‘Rhesus’ groups are of major importance. ABO blood group distribution varies in different geographical, ethnic and socio-economic groups. Apart from blood transfusion practice, knowing of the ABO and Rh blood groups were useful in population genetic studies, researching population migration patter...

OBJECTIVES The identification of epidemiological factors increasing the risk of endometriosis could shorten the time to diagnosis. Specific blood groups may be more common in patients with endometriosis. STUDY DESIGN We designed a cross-sectional study of 633 Caucasian women living in the same geographic area. Study group included 311 patients with histologically proven endometriosis. Control...

BACKGROUND It is well established that ABO and rhesus (Rh) genes and phenotypes vary widely between ethnic groups and both within and between geographical areas. The aim of this study was to determine the distribution of ABO and Rh blood groups in Kurds and to compare it with those of other populations. SUBJECTS AND METHODS The study included blood grouping of total population of 53,234 whose...

A nine-hour-old term small for date male newborn weighing 1850 g delivered by Cesarean section to an 'A' rhesus negative mother with an Rh antibody titre of 1:128, presented with pallor, icterus and mild hepatomegaly. Cord blood reports revealed an indirect serum bilirubin of 3.7 mg/dl, reticulocyte count 9%, platelet count 120,000/cu mm, hemoglobin (Hb) 9.3 g/dl, a positive direct Coomb's test...

Human red blood cells are traditionally typed as Rhesus (Rh)-positive or -negative depending on the presence or absence of the Rh D antigen. A recent report demonstrated that the Rh D gene is completely absent in Rh D-negative individuals. In this study, Rh D-negative blood donors with ccee (n = 25) and CCee (n = 3) phenotypes were examined for the presence of absence of the D gene. Polymerase ...