INTRODUCTION In 2011, some 3800 Rural Health Clinics (RHCs) delivered primary care in underserved rural areas throughout the USA. To date, little research has been conducted to identify the variability in RHC performance. In an effort to address the knowledge gaps, a national, longitudinal study was conducted of a panel of 3565 RHCs. The goals of the study were to determine: (1) the relationshi...

Quasi-static shear crack propagation in a linear elastic fluid-saturated porous solid c;Iuses a change of pore pressure on the crack plane if it is impermeable but not if it is permeable. Assuming that the pore pressure induced on the crack plane reduces the efTcclive compressive stress (total stress minus pore fluid pressure) and. as a result. the frictional resistance. we find that the energy...

The inhibitory effect of galloyl pedunculagin (GP) isolated from Platycarya strobilacea on the activity and autophosphorylation of Ca(2+)- and phospholipid-dependent protein kinase (C-kinase) was examined in vitro. It was found that (i). GP inhibited the activity (phosphorylation of complement C3 from guinea pig) of C-kinase alpha (rat brain) in a dose-dependent manner with an ID(50) of approx....

The Rh system is the most polymorphic and immunogenic for all blood group systems. Currently more than 49 antigens were identified with five major antigens D, C, c, E, e. Knowledge of the Rh system's molecular basis, since its first cloning 17 years ago, allowed to understand the mechanism of Rh-negative phenotype and the variants of antigens as RHD and RHCE. Deletions, gene rearrangements and ...

The complexity of the RHD and RHCE genes, which is the greatest of all blood group systems, confounds analysis at the molecular level. RH DNA typing was introduced in 1993 and has been applied to prenatal testing. PCR-SSP analysis covering multiple polymorphisms was recently introduced for the screening and initial characterization of partial D. Our objective is to summarize the accrued knowled...

Amide bond formation reactions are among the most important transformations in organic chemistry because of the widespread occurrence of amides in pharmaceuticals, natural products and biologically active compounds. The Beckmann rearrangement is a well-known method to generate secondary amides from ketoximes. However, under the acidic conditions commonly employed, aldoximes RHC=NOH rarely rearr...