The neural capacity (NC) of high-pass resolution perimetry (HRP) was compared to the retinal nerve fiber layer thickness measured with the GDx Nerve Fiber Analyzer in 74 patients with either ocular hypertension or primary open-angle glaucoma at various stages of severity. A statistically significant correlation was found between the NC and the GDx ellipse average, the total polar integral, and ...

OBJECTIVE To assess the internal reflectivity of the retinal nerve fiber layer in normal, ocular hypertensive, and glaucomatous eyes using optical coherence tomography. METHODS All patients underwent complete ophthalmic examination and achromatic automated perimetry. Intraocular pressure was 21 mm Hg or less for low-tension glaucoma and normal eyes and at least 25 mm Hg on 2 separate occasion...

OBJECTIVE To investigate the longitudinal corneal birefringence (corneal polarization axis [CPA] and corneal polarization magnitude [CPM]) variability in scanning laser polarimetry with variable corneal compensation and its effect on retinal nerve fiber layer measurements. Method We analyzed scanning laser polarimetry images obtained every 6 months for 3.2 years in 16 healthy eyes, 38 eyes with...

Introduction The retina may reflect Alzheimer's disease (AD) neuropathological changes and is easily visualized with optical coherence tomography (OCT). Retinal thickness decrease has been correlated to AD, however, without information on amyloid status. We correlated retinal (layer) thickness to AD biomarkers in amyloid-positive early-onset AD (EOAD) patients and amyloid-negative controls. M...

PURPOSE To develop structural markers of early glaucomatous optic nerve damage with confocal scanning laser ophthalmoscopy. METHODS Custom software was developed to analyze the images of 53 patients with open-angle glaucoma and 43 healthy subjects (matched for age, race, and refractive error), with images acquired with a confocal scanning laser ophthalmoscope. Height values were obtained alon...

Glaucoma is characterized by a combination of structural changes in the retina and optic nerve head and functional perimetric damage. Examination and documentation of the retinal nerve fiber layer are essential for the diagnosis and monitoring of glaucoma. Spectral domain Optical coherence tomography (OCT) is a high resolution imaging device capable of obtaining reproducible retinal nerve fiber...

Five monoclonal antibodies were selected by immunizing mice with embryonic chick optic nerve and screening the resultant hybridoma antibodies by immunofluorescence on sections of the retina. The optic nerve was chosen as the immunizing tissue since it is presumably enriched in ganglion cell-specific antigens. These antibodies bind to antigens which are largely localized to the inner part of the...

PURPOSE To report the findings of optical coherence tomography (OCT) in three cases of diffuse unilateral subacute neuroretinitis (DUSN). METHODS Three young patients with confirmed diagnosis of diffuse unilateral subacute neuroretinitis were followed-up using Stratus OCT. RESULTS Optical coherence tomography findings included retinal nerve fiber layer atrophy and focal edema where the worm...